A genome-wide association study of severe teenage acne in European Americans

Mingfeng Zhang, Abrar A. Qureshi, David J. Hunter, Jiali Han

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Despite the family aggregation of severe teenage acne, the genetic basis of this common skin condition remains unclear. We conducted a genome-wide association study (GWAS) on severe teenage acne in 928 European Americans. The SNP rs4133274 on chromosome 8q24 (72 kb upstream of MYC) revealed the most significant association with severe teenage acne (p value = 1.7 × 10 -6). The variant allele of this SNP (G allele) was associated with an increased risk of severe teenage acne with odds ratio of 4.01 (95 % confidence interval = 2.37-6.82). Upon further replication, our findings suggest new genetic basis of acne and may explain the association between acne and cancer risk observed in the epidemiological studies.

Original languageEnglish (US)
Pages (from-to)259-264
Number of pages6
JournalHuman Genetics
Volume133
Issue number3
DOIs
StatePublished - Mar 1 2014

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Genome-Wide Association Study
Acne Vulgaris
Single Nucleotide Polymorphism
Alleles
Epidemiologic Studies
Chromosomes
Odds Ratio
Confidence Intervals
Skin
Neoplasms

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

A genome-wide association study of severe teenage acne in European Americans. / Zhang, Mingfeng; Qureshi, Abrar A.; Hunter, David J.; Han, Jiali.

In: Human Genetics, Vol. 133, No. 3, 01.03.2014, p. 259-264.

Research output: Contribution to journalArticle

Zhang, Mingfeng ; Qureshi, Abrar A. ; Hunter, David J. ; Han, Jiali. / A genome-wide association study of severe teenage acne in European Americans. In: Human Genetics. 2014 ; Vol. 133, No. 3. pp. 259-264.
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