A genome-wide investigation of food addiction

Marilyn C. Cornelis, Alan Flint, Alison E. Field, Peter Kraft, Jiali Han, Eric B. Rimm, Rob M. van Dam

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: Evidence of parallels between drug addiction and eating behavior continues to accumulate. Genetic studies of addictive substances have yielded a number of susceptibility loci that point to common higher order genetic pathways underlying addiction. It was hypothesized that a genome-wide association study (GWAS) of food addiction would yield significant enrichment in genes and pathways linked to addiction. Methods: A GWAS of food addiction, determined by the modified Yale Food Addiction Scale (mYFAS), was conducted among 9,314 women of European ancestry, and results for enrichment of single-nucleotide polymorphisms (SNPs) (n = 44), genes (n = 238), and pathways (n = 11) implicated in drug addiction were examined. Results: Two loci met GW-significance (P < 2.5 � 10−8) mapping to 17q21.31 and 11q13.4 that harbor genes with no obvious roles in eating behavior. GW results were significantly enriched for gene members of the MAPK signaling pathway (P = 0.02). No candidate SNP or gene for drug addiction was significantly associated with food addiction after correction for multiple testing. Conclusions: In the first GWAS of mYFAS, suggestive loci worthy of further follow-up were identified, but limited support was provided for shared genetic underpinnings of food addiction and drug addiction. The latter might be due to limited study power and knowledge of the genetics of drug addiction.

Original languageEnglish (US)
Pages (from-to)1336-1341
Number of pages6
JournalObesity
Volume24
Issue number6
DOIs
StatePublished - Jun 1 2016

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Substance-Related Disorders
Genome
Food
Genome-Wide Association Study
Genes
Feeding Behavior
Single Nucleotide Polymorphism

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Cornelis, M. C., Flint, A., Field, A. E., Kraft, P., Han, J., Rimm, E. B., & van Dam, R. M. (2016). A genome-wide investigation of food addiction. Obesity, 24(6), 1336-1341. https://doi.org/10.1002/oby.21476

A genome-wide investigation of food addiction. / Cornelis, Marilyn C.; Flint, Alan; Field, Alison E.; Kraft, Peter; Han, Jiali; Rimm, Eric B.; van Dam, Rob M.

In: Obesity, Vol. 24, No. 6, 01.06.2016, p. 1336-1341.

Research output: Contribution to journalArticle

Cornelis, MC, Flint, A, Field, AE, Kraft, P, Han, J, Rimm, EB & van Dam, RM 2016, 'A genome-wide investigation of food addiction', Obesity, vol. 24, no. 6, pp. 1336-1341. https://doi.org/10.1002/oby.21476
Cornelis MC, Flint A, Field AE, Kraft P, Han J, Rimm EB et al. A genome-wide investigation of food addiction. Obesity. 2016 Jun 1;24(6):1336-1341. https://doi.org/10.1002/oby.21476
Cornelis, Marilyn C. ; Flint, Alan ; Field, Alison E. ; Kraft, Peter ; Han, Jiali ; Rimm, Eric B. ; van Dam, Rob M. / A genome-wide investigation of food addiction. In: Obesity. 2016 ; Vol. 24, No. 6. pp. 1336-1341.
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