Abstract
While behavioral genetic studies have suggested that childhood conduct disorder is under genetic influence, studies aimed at gene identification are lacking. This study represents the first genome-wide linkage analysis directed toward identifying genes contributing to conduct disorder. Genome screens of retrospectively reported childhood conduct disorder and conduct disorder symptomatology were carried out in the genetically informative adult sample collected as part of the Collaborative Study on the Genetics of Alcoholism (COGA). The results suggest that regions on chromosomes 19 and 2 may contain genes conferring risk to conduct disorder. Interestingly, the same region on chromosome 2 has also been linked to alcohol dependence in this sample. Childhood conduct disorder is known to be associated with the susceptibility for future alcohol problems. Taken together, these findings suggest that some of the genes contributing to alcohol dependence in adulthood may also contribute to conduct disorder in childhood.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 81-86 |
| Number of pages | 6 |
| Journal | Molecular Psychiatry |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 17 2004 |
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Keywords
- Alcohol dependence
- Conduct disorder
- Genetics
- Linkage analysis
ASJC Scopus subject areas
- Molecular Biology
- Psychiatry and Mental health
Cite this
A genome-wide screen for genes influencing conduct disorder. / Dick, D. M.; Li, T. K.; Edenberg, H. J.; Hesselbrock, V.; Kramer, J.; Kuperman, S.; Porjesz, B.; Bucholz, K.; Goate, A.; Nurnberger, J.; Foroud, T.
In: Molecular Psychiatry, Vol. 9, No. 1, 17.02.2004, p. 81-86.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A genome-wide screen for genes influencing conduct disorder
AU - Dick, D. M.
AU - Li, T. K.
AU - Edenberg, H. J.
AU - Hesselbrock, V.
AU - Kramer, J.
AU - Kuperman, S.
AU - Porjesz, B.
AU - Bucholz, K.
AU - Goate, A.
AU - Nurnberger, J.
AU - Foroud, T.
PY - 2004/2/17
Y1 - 2004/2/17
N2 - While behavioral genetic studies have suggested that childhood conduct disorder is under genetic influence, studies aimed at gene identification are lacking. This study represents the first genome-wide linkage analysis directed toward identifying genes contributing to conduct disorder. Genome screens of retrospectively reported childhood conduct disorder and conduct disorder symptomatology were carried out in the genetically informative adult sample collected as part of the Collaborative Study on the Genetics of Alcoholism (COGA). The results suggest that regions on chromosomes 19 and 2 may contain genes conferring risk to conduct disorder. Interestingly, the same region on chromosome 2 has also been linked to alcohol dependence in this sample. Childhood conduct disorder is known to be associated with the susceptibility for future alcohol problems. Taken together, these findings suggest that some of the genes contributing to alcohol dependence in adulthood may also contribute to conduct disorder in childhood.
AB - While behavioral genetic studies have suggested that childhood conduct disorder is under genetic influence, studies aimed at gene identification are lacking. This study represents the first genome-wide linkage analysis directed toward identifying genes contributing to conduct disorder. Genome screens of retrospectively reported childhood conduct disorder and conduct disorder symptomatology were carried out in the genetically informative adult sample collected as part of the Collaborative Study on the Genetics of Alcoholism (COGA). The results suggest that regions on chromosomes 19 and 2 may contain genes conferring risk to conduct disorder. Interestingly, the same region on chromosome 2 has also been linked to alcohol dependence in this sample. Childhood conduct disorder is known to be associated with the susceptibility for future alcohol problems. Taken together, these findings suggest that some of the genes contributing to alcohol dependence in adulthood may also contribute to conduct disorder in childhood.
KW - Alcohol dependence
KW - Conduct disorder
KW - Genetics
KW - Linkage analysis
UR - http://www.scopus.com/inward/record.url?scp=0842264948&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0842264948&partnerID=8YFLogxK
U2 - 10.1038/sj.mp.4001368
DO - 10.1038/sj.mp.4001368
M3 - Article
C2 - 14699444
AN - SCOPUS:0842264948
VL - 9
SP - 81
EP - 86
JO - Molecular Psychiatry
JF - Molecular Psychiatry
SN - 1359-4184
IS - 1
ER -