A genome-wide search for genes that relate to a low level of response to alcohol

M. A. Schuckit, Howard Edenberg, J. Kalmijn, L. Flury, T. L. Smith, T. Reich, L. Bierut, A. Goate, Tatiana Foroud

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

Background: The low level of response (LR) to alcohol is genetically influenced in both humans and animals, and a low LR is a characteristic of offspring of alcoholics that has been reported to predict alcoholism 10 and 15 years later. The genes that contribute to a low LR have not yet been identified. Methods: A 12-item questionnaire that measures LR, the Self Rating of the Effects of Alcohol (SRE) instrument, was filled out by 745 individuals from the Collaborative Study on the Genetics of Alcoholism (COGA) for whom genetic material was available. These subjects were genotyped by using 336 markers with an average heterozygosity of 0.74 and an average intermarker distance of 10.5 cM. Both quantitative and qualitative nonparametric, sib-pair analyses were carried out for the SRE measure related to early drinking experiences. Results: Correlations of SRE scores across related individuals were significant and between 0.16 and 0.22 for most values, compared with nonsignificant correlations of 0.03 or less among unrelated individuals. Linkage analyses performed by using the FIRST 5 variables (first five times alcohol is consumed) identified four chromosomal regions with lod scores ≥2.0 whose maximum was also near a marker. One of these chromosomal regions previously was linked to alcohol dependence in the COGA sample. Conclusions: These data document the familial nature of a low LR to alcohol as measured by the SRE and suggest several chromosomal regions that might contribute to the phenomenon.

Original languageEnglish
Pages (from-to)323-329
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Volume25
Issue number3
StatePublished - 2001

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Alcoholism
Genes
Alcohols
Genome
Lod Score
compound A 12
Alcoholics
Drinking
Animals
Genetics

Keywords

  • Alcoholism
  • Genetics
  • Reaction

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

A genome-wide search for genes that relate to a low level of response to alcohol. / Schuckit, M. A.; Edenberg, Howard; Kalmijn, J.; Flury, L.; Smith, T. L.; Reich, T.; Bierut, L.; Goate, A.; Foroud, Tatiana.

In: Alcoholism: Clinical and Experimental Research, Vol. 25, No. 3, 2001, p. 323-329.

Research output: Contribution to journalArticle

Schuckit, MA, Edenberg, H, Kalmijn, J, Flury, L, Smith, TL, Reich, T, Bierut, L, Goate, A & Foroud, T 2001, 'A genome-wide search for genes that relate to a low level of response to alcohol', Alcoholism: Clinical and Experimental Research, vol. 25, no. 3, pp. 323-329.
Schuckit, M. A. ; Edenberg, Howard ; Kalmijn, J. ; Flury, L. ; Smith, T. L. ; Reich, T. ; Bierut, L. ; Goate, A. ; Foroud, Tatiana. / A genome-wide search for genes that relate to a low level of response to alcohol. In: Alcoholism: Clinical and Experimental Research. 2001 ; Vol. 25, No. 3. pp. 323-329.
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