A homolog of the proteasome-related RING10 gene is essential for yeast cell growth

Haya Friedman, Mark Goebel, Michael Snyder

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Proteasomes are intracellular protein complexes displaying multiproteolytic activities. These complexes have been implicated in the antigen degradation process that generates peptides associated with the major histocompatibility complex (MHC) class-I molecule. RING10 and RING12 are genes encoded by the class-II region of the human MHC that have sequence homology to proteasome-encoding genes. We have identified a yeast gene, called PRG1, that encodes a protein predicted to contain 55.6% sequence identity to 80% of the RING10 gene product. Genomic disruption of PRG1 revealed that it is essential for yeast cell growth. These data strongly indicate that the antigen-processing system present in vertebrates evolved from a basic cellular process present in all organisms.

Original languageEnglish (US)
Pages (from-to)203-206
Number of pages4
JournalGene
Volume122
Issue number1
DOIs
StatePublished - Dec 1 1992

Keywords

  • PRG1
  • Saccharomyces cerevisiae
  • antigen degradation
  • proteolysis

ASJC Scopus subject areas

  • Genetics

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