A KCNJ6 gene polymorphism modulates theta oscillations during reward processing

Chella Kamarajan, Ashwini K. Pandey, David B. Chorlian, Niklas Manz, Arthur T. Stimus, Howard Edenberg, Leah Wetherill, Marc Schuckit, Jen Chyong Wang, Samuel Kuperman, John Kramer, Jay A. Tischfield, Bernice Porjesz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Event related oscillations (EROs) are heritable measures of neurocognitive function that have served as useful phenotype in genetic research. A recent family genome-wide association study (GWAS) by the Collaborative Study on the Genetics of Alcoholism (COGA) found that theta EROs during visual target detection were associated at genome-wide levels with several single nucleotide polymorphisms (SNPs), including a synonymous SNP, rs702859, in the . KCNJ6 gene that encodes GIRK2, a G-protein inward rectifying potassium channel that regulates excitability of neuronal networks. The present study examined the effect of the . KCNJ6 SNP (rs702859), previously associated with theta ERO to targets in a visual oddball task, on theta EROs during reward processing in a monetary gambling task. The participants were 1601 adolescent and young adult offspring within the age-range of 17-25. years (800 males and 801 females) from high-dense alcoholism families as well as control families of the COGA prospective study. Theta ERO power (3.5-7.5. Hz, 200-500. ms post-stimulus) was compared across genotype groups. ERO theta power at central and parietal regions increased as a function of the minor allele (A) dose in the genotype (AA.>. AG.>. GG) in both loss and gain conditions. These findings indicate that variations in the . KCNJ6 SNP influence magnitude of theta oscillations at posterior loci during the evaluation of loss and gain, reflecting a genetic influence on neuronal circuits involved in reward-processing. Increased theta power as a function of minor allele dose suggests more efficient cognitive processing in those carrying the minor allele of the . KCNJ6 SNPs. Future studies are needed to determine the implications of these genetic effects on posterior theta EROs as possible protective factors, or as indices of delays in brain maturation (i.e., lack of frontalization).

Original languageEnglish (US)
JournalInternational Journal of Psychophysiology
DOIs
StateAccepted/In press - Oct 5 2015

Fingerprint

Reward
Single Nucleotide Polymorphism
Alcoholism
Genes
Alleles
Genotype
Genetic Research
Gambling
Parietal Lobe
Genome-Wide Association Study
Potassium Channels
Adult Children
GTP-Binding Proteins
Young Adult
Genome
Prospective Studies
Phenotype
Brain
Power (Psychology)

Keywords

  • Alcoholism
  • COGA
  • Event-related oscillations (EROs)
  • GIRK2
  • KCNJ6
  • Monetary gambling task
  • Reward processing
  • Theta power

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Physiology (medical)

Cite this

A KCNJ6 gene polymorphism modulates theta oscillations during reward processing. / Kamarajan, Chella; Pandey, Ashwini K.; Chorlian, David B.; Manz, Niklas; Stimus, Arthur T.; Edenberg, Howard; Wetherill, Leah; Schuckit, Marc; Wang, Jen Chyong; Kuperman, Samuel; Kramer, John; Tischfield, Jay A.; Porjesz, Bernice.

In: International Journal of Psychophysiology, 05.10.2015.

Research output: Contribution to journalArticle

Kamarajan, C, Pandey, AK, Chorlian, DB, Manz, N, Stimus, AT, Edenberg, H, Wetherill, L, Schuckit, M, Wang, JC, Kuperman, S, Kramer, J, Tischfield, JA & Porjesz, B 2015, 'A KCNJ6 gene polymorphism modulates theta oscillations during reward processing', International Journal of Psychophysiology. https://doi.org/10.1016/j.ijpsycho.2016.12.007
Kamarajan, Chella ; Pandey, Ashwini K. ; Chorlian, David B. ; Manz, Niklas ; Stimus, Arthur T. ; Edenberg, Howard ; Wetherill, Leah ; Schuckit, Marc ; Wang, Jen Chyong ; Kuperman, Samuel ; Kramer, John ; Tischfield, Jay A. ; Porjesz, Bernice. / A KCNJ6 gene polymorphism modulates theta oscillations during reward processing. In: International Journal of Psychophysiology. 2015.
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abstract = "Event related oscillations (EROs) are heritable measures of neurocognitive function that have served as useful phenotype in genetic research. A recent family genome-wide association study (GWAS) by the Collaborative Study on the Genetics of Alcoholism (COGA) found that theta EROs during visual target detection were associated at genome-wide levels with several single nucleotide polymorphisms (SNPs), including a synonymous SNP, rs702859, in the . KCNJ6 gene that encodes GIRK2, a G-protein inward rectifying potassium channel that regulates excitability of neuronal networks. The present study examined the effect of the . KCNJ6 SNP (rs702859), previously associated with theta ERO to targets in a visual oddball task, on theta EROs during reward processing in a monetary gambling task. The participants were 1601 adolescent and young adult offspring within the age-range of 17-25. years (800 males and 801 females) from high-dense alcoholism families as well as control families of the COGA prospective study. Theta ERO power (3.5-7.5. Hz, 200-500. ms post-stimulus) was compared across genotype groups. ERO theta power at central and parietal regions increased as a function of the minor allele (A) dose in the genotype (AA.>. AG.>. GG) in both loss and gain conditions. These findings indicate that variations in the . KCNJ6 SNP influence magnitude of theta oscillations at posterior loci during the evaluation of loss and gain, reflecting a genetic influence on neuronal circuits involved in reward-processing. Increased theta power as a function of minor allele dose suggests more efficient cognitive processing in those carrying the minor allele of the . KCNJ6 SNPs. Future studies are needed to determine the implications of these genetic effects on posterior theta EROs as possible protective factors, or as indices of delays in brain maturation (i.e., lack of frontalization).",
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