Abstract
A critical factor in the transmission and pathogenesis of Toxoplasma gondii is the ability to convert from an acute disease-causing, proliferative stage (tachyzoite), to a chronic, dormant stage (bradyzoite). The conversion of the tachyzoite-containing parasitophorous vacuole membrane into the less permeable bradyzoite cyst wall allows the parasite to persist for years within the host to maximize transmissibility to both primary (felids) and secondary (virtually all other warm-blooded vertebrates) hosts. This review presents our current understanding of the latent stage, including the factors that are important in bradyzoite induction and maintenance. Also discussed are the recent studies that have begun to unravel the mechanisms behind stage switching.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-19 |
| Number of pages | 19 |
| Journal | Cellular and Molecular Life Sciences |
| DOIs | |
| State | Accepted/In press - Mar 30 2018 |
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Keywords
- Bradyzoite
- Differentiation
- Encystation
- Epigenetics
- Gene regulation
- Immunity
- Latency
- Tachyzoite
- Toxoplasma
- Toxoplasmosis
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Cellular and Molecular Neuroscience
- Cell Biology
Cite this
A latent ability to persist : differentiation in Toxoplasma gondii. / Jeffers, Victoria; Tampaki, Zoi; Kim, Kami; Sullivan, William.
In: Cellular and Molecular Life Sciences, 30.03.2018, p. 1-19.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A latent ability to persist
T2 - differentiation in Toxoplasma gondii
AU - Jeffers, Victoria
AU - Tampaki, Zoi
AU - Kim, Kami
AU - Sullivan, William
PY - 2018/3/30
Y1 - 2018/3/30
N2 - A critical factor in the transmission and pathogenesis of Toxoplasma gondii is the ability to convert from an acute disease-causing, proliferative stage (tachyzoite), to a chronic, dormant stage (bradyzoite). The conversion of the tachyzoite-containing parasitophorous vacuole membrane into the less permeable bradyzoite cyst wall allows the parasite to persist for years within the host to maximize transmissibility to both primary (felids) and secondary (virtually all other warm-blooded vertebrates) hosts. This review presents our current understanding of the latent stage, including the factors that are important in bradyzoite induction and maintenance. Also discussed are the recent studies that have begun to unravel the mechanisms behind stage switching.
AB - A critical factor in the transmission and pathogenesis of Toxoplasma gondii is the ability to convert from an acute disease-causing, proliferative stage (tachyzoite), to a chronic, dormant stage (bradyzoite). The conversion of the tachyzoite-containing parasitophorous vacuole membrane into the less permeable bradyzoite cyst wall allows the parasite to persist for years within the host to maximize transmissibility to both primary (felids) and secondary (virtually all other warm-blooded vertebrates) hosts. This review presents our current understanding of the latent stage, including the factors that are important in bradyzoite induction and maintenance. Also discussed are the recent studies that have begun to unravel the mechanisms behind stage switching.
KW - Bradyzoite
KW - Differentiation
KW - Encystation
KW - Epigenetics
KW - Gene regulation
KW - Immunity
KW - Latency
KW - Tachyzoite
KW - Toxoplasma
KW - Toxoplasmosis
UR - http://www.scopus.com/inward/record.url?scp=85044619340&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044619340&partnerID=8YFLogxK
U2 - 10.1007/s00018-018-2808-x
DO - 10.1007/s00018-018-2808-x
M3 - Article
SP - 1
EP - 19
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
SN - 1420-682X
ER -