A manufacturable smart dressing with oxygen delivery and sensing capability for chronic wound management

M. Ochoa, R. Rahimi, J. Zhou, H. Jiang, C. K. Yoon, M. Oscai, V. Jain, T. Morken, R. H. Oliveira, D. Maddipatla, B. B. Narakathu, G. L. Campana, M. A. Zieger, R. Sood, M. Z. Atashbar, B. Ziaie

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Scopus citations

Abstract

Chronic non-healing wounds, impact over 6.5 million Americans, costs in excess of $25 billion to treat on an annual basis and its incidence is predicted to rise due to the prevalence of obesity and type-2 diabetes. One of the primary complications often associated with chronic wounds is the improper functionality of the peripheral vasculature to deliver O2-rich blood to the tissue which leads to wound hypoxia. Although hyperbaric oxygen therapy are widely used and accepted as an effective approach to bolster tissue O2 levels in hypoxic chronic wounds, most of such treatments require bulky equipment and often expose large areas of the body to unnecessarily elevated oxygen concentrations that can damage healthy tissue. In this paper, we present a smart low-cost wound dressing with integrated oxygen sensor and delivery for locally generating and delivering oxygen to selected hypoxic regions on the wound. The dressing is fabricated on a biocompatible water resistant/hydrophobic paper-based substrate with printed optical oxygen sensors and patterned catalytic oxygen generating regions that are connected to a flexible microfluidic systems. Oxygen generation occurs by flowing H2O2 through the channels and chemical decomposition at the catalyst printed regions on the paper substrate. The hydrophobic paper provides structural stability and flexibility while simultaneously offering printability, selective gaseous filtering, and physical/chemical protection. The fabrication process take advantage of scalable manufacturing technologies including laser processing, inkjet printing, and lamination.

Original languageEnglish (US)
Title of host publicationMicro- and Nanotechnology Sensors, Systems, and Applications X
EditorsM. Saif Islam, Thomas George, Achyut K. Dutta
PublisherSPIE
ISBN (Electronic)9781510617896
DOIs
StatePublished - Jan 1 2018
Event2018 Micro- and Nanotechnology (MNT) Sensors, Systems, and Applications X Conference - Orlando, United States
Duration: Apr 15 2018Apr 19 2018

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume10639
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Other

Other2018 Micro- and Nanotechnology (MNT) Sensors, Systems, and Applications X Conference
CountryUnited States
CityOrlando
Period4/15/184/19/18

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Keywords

  • Chronic wound
  • Flexible bioelectronics.
  • Oxygen generation
  • Oxygen sensor
  • Smart dressing

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Ochoa, M., Rahimi, R., Zhou, J., Jiang, H., Yoon, C. K., Oscai, M., Jain, V., Morken, T., Oliveira, R. H., Maddipatla, D., Narakathu, B. B., Campana, G. L., Zieger, M. A., Sood, R., Atashbar, M. Z., & Ziaie, B. (2018). A manufacturable smart dressing with oxygen delivery and sensing capability for chronic wound management. In M. S. Islam, T. George, & A. K. Dutta (Eds.), Micro- and Nanotechnology Sensors, Systems, and Applications X [106391C] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10639). SPIE. https://doi.org/10.1117/12.2306083