A Meta-analysis of Methods to Prevent Venous Thromboembolism Following Total Hip Replacement

Thomas Imperiale, Theodore Speroff

Research output: Contribution to journalArticle

244 Citations (Scopus)

Abstract

While several methods of prophylaxis have been shown to reduce the risk of venous thromboembolism following total hip replacement, the safest and most effective agent is unclear. To clarify this issue, we performed a meta-analysis of the randomized trials of methods used to prevent venous thromboembolism following total hip replacement. —English-language human studies articles from 1966 through 1993 were obtained from a MEDLINE database search with indexing terms including thromboembolism, hip replacement or hip prosthesis, and randomized controlled trials. Additional references were obtained from study bibliographies. —The following criteria were used to select studies for inclusion: study design—randomized clinical trial; study population—patients undergoing elective total hip replacement; interventions—aspirin, warfarin, dextran, heparin, low-molecular-weight heparin, compression stockings; and outcomes— venous thromboembolism, major hemorrhage. —Methodological and descriptive data from each study were abstracted by one author who was blinded to quantitative outcomes data. —Ninety-one treatment groups and 25 control groups were identified from 56 trials. Four treatment groups were excluded because of rarely used combinations. Trial populations were clinically homogeneous. When compared with the control arm, all treatments except aspirin reduced the risk of all deep venous thromboses (risk differences range, 0.18 to 0.31; all P values

Original languageEnglish (US)
Pages (from-to)1780-1785
Number of pages6
JournalJournal of the American Medical Association
Volume271
Issue number22
DOIs
StatePublished - Jun 8 1994
Externally publishedYes

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Hip Replacement Arthroplasties
Venous Thromboembolism
Meta-Analysis
Compression Stockings
Hip Prosthesis
Low Molecular Weight Heparin
Thromboembolism
Bibliography
Warfarin
Dextrans
MEDLINE
Venous Thrombosis
Aspirin
Heparin
Hip
Arm
Language
Therapeutics
Randomized Controlled Trials
Clinical Trials

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A Meta-analysis of Methods to Prevent Venous Thromboembolism Following Total Hip Replacement. / Imperiale, Thomas; Speroff, Theodore.

In: Journal of the American Medical Association, Vol. 271, No. 22, 08.06.1994, p. 1780-1785.

Research output: Contribution to journalArticle

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