A method to the madness: Producing the neonatal ventral hippocampal lesion rat model of schizophrenia

R. Andrew Chambers, Barbara K. Lipska

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

The neonatal ventral hippocampal lesion (NVHL) rat model of schizophrenia has demonstrated broad heuristic utility as an investigative platform encompassing many of the behavioral, neurobiological, and developmental aspects of this devastating neuropsychiatric illness affecting 1% of all human beings. This chapter serves as an essential description of materials and methods for generating and verifying the NVHL model in rats, which continues to hold significant potential in helping us understand schizophrenia, co-morbid disorders, and their neurodevelopmental dynamics. Many of the approaches described here can be modified or adapted for producing other types of neurodevelopmental models of behavioral disorders.

Original languageEnglish (US)
Title of host publicationAnimal Models of Schizophrenia and Related Disorders
EditorsPatrick O'Donnell
Pages1-24
Number of pages24
DOIs
StatePublished - Jul 1 2011

Publication series

NameNeuromethods
Volume59
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

    Fingerprint

Keywords

  • ibotenic acid
  • methods
  • neonatal lesions
  • neurodevelopmental
  • Ventral hippocampus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Chambers, R. A., & Lipska, B. K. (2011). A method to the madness: Producing the neonatal ventral hippocampal lesion rat model of schizophrenia. In P. O'Donnell (Ed.), Animal Models of Schizophrenia and Related Disorders (pp. 1-24). (Neuromethods; Vol. 59). https://doi.org/10.1007/978-1-61779-157-4_1