A microRNA component of the hypoxic response

R. Kulshreshtha, R. V. Davuluri, G. A. Calin, Mircea Ivan

Research output: Contribution to journalArticle

190 Citations (Scopus)

Abstract

microRNAs participate in a wide variety of physiological and pathological cellular processes. Recent studies have established a link between a specific group of microRNAs and hypoxia, a key feature of the neoplastic microenvironment. A significant proportion of the hypoxia-regulated microRNAs (HRMs) are also overexpressed in human cancers, suggesting a role in tumorigenesis. Preliminary evidence suggests that they could affect important processes such as apoptosis, proliferation and angiogenesis. Several HRMs exhibit induction in response to HIF activation, thus extending its repertoire of targets beyond translated genes. In the present review, we discuss the emerging roles of HRMs in oxygen deprivation in cancer context.

Original languageEnglish (US)
Pages (from-to)667-671
Number of pages5
JournalCell Death and Differentiation
Volume15
Issue number4
DOIs
StatePublished - Apr 2008
Externally publishedYes

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MicroRNAs
Pathologic Processes
Neoplasms
Carcinogenesis
Apoptosis
Oxygen
Hypoxia
Genes

ASJC Scopus subject areas

  • Cell Biology

Cite this

A microRNA component of the hypoxic response. / Kulshreshtha, R.; Davuluri, R. V.; Calin, G. A.; Ivan, Mircea.

In: Cell Death and Differentiation, Vol. 15, No. 4, 04.2008, p. 667-671.

Research output: Contribution to journalArticle

Kulshreshtha, R, Davuluri, RV, Calin, GA & Ivan, M 2008, 'A microRNA component of the hypoxic response', Cell Death and Differentiation, vol. 15, no. 4, pp. 667-671. https://doi.org/10.1038/sj.cdd.4402310
Kulshreshtha, R. ; Davuluri, R. V. ; Calin, G. A. ; Ivan, Mircea. / A microRNA component of the hypoxic response. In: Cell Death and Differentiation. 2008 ; Vol. 15, No. 4. pp. 667-671.
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