A microRNA component of the hypoxic response

R. Kulshreshtha, R. V. Davuluri, G. A. Calin, M. Ivan

Research output: Contribution to journalReview article

193 Scopus citations

Abstract

microRNAs participate in a wide variety of physiological and pathological cellular processes. Recent studies have established a link between a specific group of microRNAs and hypoxia, a key feature of the neoplastic microenvironment. A significant proportion of the hypoxia-regulated microRNAs (HRMs) are also overexpressed in human cancers, suggesting a role in tumorigenesis. Preliminary evidence suggests that they could affect important processes such as apoptosis, proliferation and angiogenesis. Several HRMs exhibit induction in response to HIF activation, thus extending its repertoire of targets beyond translated genes. In the present review, we discuss the emerging roles of HRMs in oxygen deprivation in cancer context.

Original languageEnglish (US)
Pages (from-to)667-671
Number of pages5
JournalCell Death and Differentiation
Volume15
Issue number4
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'A microRNA component of the hypoxic response'. Together they form a unique fingerprint.

  • Cite this