A microRNA signature of hypoxia

Ritu Kulshreshtha, Manuela Ferracin, Sylwia E. Wojcik, Ramiro Garzon, Hansjuerg Alder, Francisco J. Agosto-Perez, Ramana Davuluri, Chang Gong Liu, Carlo M. Croce, Massimo Negrini, George A. Calin, Mircea Ivan

Research output: Contribution to journalArticle

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Abstract

Recent research has identified critical roles for microRNAs in a large number of cellular processes, including tumorigenic transformation. While significant progress has been made towards understanding the mechanisms of gene regulation by microRNAs, much less is known about factors affecting the expression of these noncoding transcripts. Here, we demonstrate for the first time a functional link between hypoxia, a well-documented tumor microenvironment factor, and microRNA expression. Microarray-based expression profiles revealed that a specific spectrum of microRNAs (including miR-23, -24, -26, -27, -103, -107, -181, -210, and -213) is induced in response to low oxygen, at least some via a hypoxia-inducible-factor-dependent mechanism. Select members of this group (miR-26, -107, and -210) decrease proapoptotic signaling in a hypoxic environment, suggesting an impact of these transcripts on tumor formation. Interestingly, the vast majority of hypoxia-induced microRNAs are also overexpressed in a variety of human tumors.

Original languageEnglish (US)
Pages (from-to)1859-1867
Number of pages9
JournalMolecular and Cellular Biology
Volume27
Issue number5
DOIs
StatePublished - Mar 2007
Externally publishedYes

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MicroRNAs
Neoplastic Cell Transformation
Tumor Microenvironment
Neoplasms
Hypoxia
Oxygen
Research
Genes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Kulshreshtha, R., Ferracin, M., Wojcik, S. E., Garzon, R., Alder, H., Agosto-Perez, F. J., ... Ivan, M. (2007). A microRNA signature of hypoxia. Molecular and Cellular Biology, 27(5), 1859-1867. https://doi.org/10.1128/MCB.01395-06

A microRNA signature of hypoxia. / Kulshreshtha, Ritu; Ferracin, Manuela; Wojcik, Sylwia E.; Garzon, Ramiro; Alder, Hansjuerg; Agosto-Perez, Francisco J.; Davuluri, Ramana; Liu, Chang Gong; Croce, Carlo M.; Negrini, Massimo; Calin, George A.; Ivan, Mircea.

In: Molecular and Cellular Biology, Vol. 27, No. 5, 03.2007, p. 1859-1867.

Research output: Contribution to journalArticle

Kulshreshtha, R, Ferracin, M, Wojcik, SE, Garzon, R, Alder, H, Agosto-Perez, FJ, Davuluri, R, Liu, CG, Croce, CM, Negrini, M, Calin, GA & Ivan, M 2007, 'A microRNA signature of hypoxia', Molecular and Cellular Biology, vol. 27, no. 5, pp. 1859-1867. https://doi.org/10.1128/MCB.01395-06
Kulshreshtha R, Ferracin M, Wojcik SE, Garzon R, Alder H, Agosto-Perez FJ et al. A microRNA signature of hypoxia. Molecular and Cellular Biology. 2007 Mar;27(5):1859-1867. https://doi.org/10.1128/MCB.01395-06
Kulshreshtha, Ritu ; Ferracin, Manuela ; Wojcik, Sylwia E. ; Garzon, Ramiro ; Alder, Hansjuerg ; Agosto-Perez, Francisco J. ; Davuluri, Ramana ; Liu, Chang Gong ; Croce, Carlo M. ; Negrini, Massimo ; Calin, George A. ; Ivan, Mircea. / A microRNA signature of hypoxia. In: Molecular and Cellular Biology. 2007 ; Vol. 27, No. 5. pp. 1859-1867.
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