A microRNA signature of hypoxia

Ritu Kulshreshtha, Manuela Ferracin, Sylwia E. Wojcik, Ramiro Garzon, Hansjuerg Alder, Francisco J. Agosto-Perez, Ramana Davuluri, Chang Gong Liu, Carlo M. Croce, Massimo Negrini, George A. Calin, Mircea Ivan

Research output: Contribution to journalArticlepeer-review

800 Scopus citations

Abstract

Recent research has identified critical roles for microRNAs in a large number of cellular processes, including tumorigenic transformation. While significant progress has been made towards understanding the mechanisms of gene regulation by microRNAs, much less is known about factors affecting the expression of these noncoding transcripts. Here, we demonstrate for the first time a functional link between hypoxia, a well-documented tumor microenvironment factor, and microRNA expression. Microarray-based expression profiles revealed that a specific spectrum of microRNAs (including miR-23, -24, -26, -27, -103, -107, -181, -210, and -213) is induced in response to low oxygen, at least some via a hypoxia-inducible-factor-dependent mechanism. Select members of this group (miR-26, -107, and -210) decrease proapoptotic signaling in a hypoxic environment, suggesting an impact of these transcripts on tumor formation. Interestingly, the vast majority of hypoxia-induced microRNAs are also overexpressed in a variety of human tumors.

Original languageEnglish (US)
Pages (from-to)1859-1867
Number of pages9
JournalMolecular and cellular biology
Volume27
Issue number5
DOIs
StatePublished - Mar 2007

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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