A molecular genetic model of human bladder carcinogenesis

Catherine A. Reznikoff, Chinghai Kao, Edward M. Messing, Michael Newton, Santhanam Swaminathan

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Human bladder carcinogenesis stands as a paradigm for research on the molecular genetic mechanisms of chemical carcinogenesis. The pathogenesis of bladder cancer is multistage with a typical onset later in life. Epidemiological studies associate occupational exposure to aromatic amines with increased bladder cancer risk. Biochemical studies show aromatic amine metabolism, covalent binding, and DNA adduct formation in human uroepithelial cells (HUC). Smoking increases bladder cancer risk. A possible link with certain strains of human papilloma virus (HPV) infection has recently been suggested. Molecular analyses of bladder cancers reveal multiple genetic alterations, including mutational activation of oncogenes and inactivation of suppressor genes. A working hypothesis proposes that bladder carcinogens cause mutations in cancer genes (oncogenes and suppressor genes) in HUC that, possibly together with HPV infection and viral DNA integration, lead to the development of bladder cancer. In this review, we describe how this model is currently being tested using a multistep HUC in vitro transformation system.

Original languageEnglish (US)
Pages (from-to)143-152
Number of pages10
JournalSeminars in Cancer Biology
Volume4
Issue number3
StatePublished - 1993
Externally publishedYes

Fingerprint

Molecular Models
Genetic Models
Urinary Bladder Neoplasms
Molecular Biology
Carcinogenesis
Urinary Bladder
Papillomaviridae
Suppressor Genes
Virus Diseases
Oncogenes
Amines
Virus Integration
DNA Adducts
Neoplasm Genes
Viral DNA
Occupational Exposure
Carcinogens
Epidemiologic Studies
Smoking
Mutation

Keywords

  • Aromatic amines
  • Bladder cancer
  • Oncogenes and suppressor genes
  • Transformation in vitro

ASJC Scopus subject areas

  • Cancer Research

Cite this

Reznikoff, C. A., Kao, C., Messing, E. M., Newton, M., & Swaminathan, S. (1993). A molecular genetic model of human bladder carcinogenesis. Seminars in Cancer Biology, 4(3), 143-152.

A molecular genetic model of human bladder carcinogenesis. / Reznikoff, Catherine A.; Kao, Chinghai; Messing, Edward M.; Newton, Michael; Swaminathan, Santhanam.

In: Seminars in Cancer Biology, Vol. 4, No. 3, 1993, p. 143-152.

Research output: Contribution to journalArticle

Reznikoff, CA, Kao, C, Messing, EM, Newton, M & Swaminathan, S 1993, 'A molecular genetic model of human bladder carcinogenesis', Seminars in Cancer Biology, vol. 4, no. 3, pp. 143-152.
Reznikoff CA, Kao C, Messing EM, Newton M, Swaminathan S. A molecular genetic model of human bladder carcinogenesis. Seminars in Cancer Biology. 1993;4(3):143-152.
Reznikoff, Catherine A. ; Kao, Chinghai ; Messing, Edward M. ; Newton, Michael ; Swaminathan, Santhanam. / A molecular genetic model of human bladder carcinogenesis. In: Seminars in Cancer Biology. 1993 ; Vol. 4, No. 3. pp. 143-152.
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