A multi-center 1H MRS study of the AIDS dementia complex: Validation and preliminary analysis

Patricia Lani Lee, Constantin Yiannoutsos, Thomas Ernst, Linda Chang, Christina M. Marra, Jeffrey G. Jarvik, Todd L. Richards, Edmund W. Kwok, Dennis L. Kolson, David Simpson, Cheuk Y. Tang, Giovanni Schifitto, Leena M. Ketonen, Dieter J. Meyerhoff, Robert E. Lenkinski, R. Gilberto Gonzalez, Bradford A. Navia

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Purpose: To demonstrate the technical feasibility and reliability of a multi-center study characterizing regional levels of the brain metabolite ratios choline (Cho)/creatine (Cr) and myoinositol (MI)/Cr, markers of glial cell activity, and N-acetyl aspartate (NAA)/Cr, a marker of mature neurons, in subjects with AIDS dementia complex (ADC). Materials and Methods: Using an automated protocol (GE PROBE-P), short echo time spectra (TE = 35 msec) were obtained at eight sites from uniformly prepared phantoms and from three brain regions (frontal white matter, basal ganglia, and parietal cortex) of normal volunteers and ADC and HIV-negative subjects. Results: A random-effects model of the phantom and volunteer data showed no significant inter-site differences. Feasibility of a multi-center study was further validated by detection of significant differences between the metabolite ratios of ADC subjects and HIV-negative controls. ADC subjects exhibited significantly higher Cho/Cr and MI/Cr in the basal ganglia and significantly reduced NAA/Cr and significantly higher MI/Cr in the frontal white matter. These results are consistent with the predominantly subcortical distribution of the pathologic abnormalities associated with ADC. Conclusion: This is the first study to ascertain and validate the reliability and reproducibility of a short echo time 1HMRS acquisition sequence from multiple brain regions in a multi-center setting. It should now be possible to examine the regional effects of HIV infection in the brain in a large number of subjects and to study the metabolic effects of new therapies for the treatment of ADC in a clinical trial setting.

Original languageEnglish (US)
Pages (from-to)625-633
Number of pages9
JournalJournal of magnetic resonance imaging : JMRI
Volume17
Issue number6
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

Fingerprint

AIDS Dementia Complex
Creatine
Inositol
Brain
Choline
Basal Ganglia
HIV
Parietal Lobe
Proton Magnetic Resonance Spectroscopy
Neuroglia
HIV Infections
Volunteers
Healthy Volunteers
Clinical Trials
Neurons
Therapeutics

Keywords

  • AIDS dementia complex (ADC)
  • HIV infection
  • MRS
  • Neuroimaging
  • Spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

A multi-center 1H MRS study of the AIDS dementia complex : Validation and preliminary analysis. / Lee, Patricia Lani; Yiannoutsos, Constantin; Ernst, Thomas; Chang, Linda; Marra, Christina M.; Jarvik, Jeffrey G.; Richards, Todd L.; Kwok, Edmund W.; Kolson, Dennis L.; Simpson, David; Tang, Cheuk Y.; Schifitto, Giovanni; Ketonen, Leena M.; Meyerhoff, Dieter J.; Lenkinski, Robert E.; Gonzalez, R. Gilberto; Navia, Bradford A.

In: Journal of magnetic resonance imaging : JMRI, Vol. 17, No. 6, 01.06.2003, p. 625-633.

Research output: Contribution to journalArticle

Lee, PL, Yiannoutsos, C, Ernst, T, Chang, L, Marra, CM, Jarvik, JG, Richards, TL, Kwok, EW, Kolson, DL, Simpson, D, Tang, CY, Schifitto, G, Ketonen, LM, Meyerhoff, DJ, Lenkinski, RE, Gonzalez, RG & Navia, BA 2003, 'A multi-center 1H MRS study of the AIDS dementia complex: Validation and preliminary analysis', Journal of magnetic resonance imaging : JMRI, vol. 17, no. 6, pp. 625-633. https://doi.org/10.1002/jmri.10295
Lee, Patricia Lani ; Yiannoutsos, Constantin ; Ernst, Thomas ; Chang, Linda ; Marra, Christina M. ; Jarvik, Jeffrey G. ; Richards, Todd L. ; Kwok, Edmund W. ; Kolson, Dennis L. ; Simpson, David ; Tang, Cheuk Y. ; Schifitto, Giovanni ; Ketonen, Leena M. ; Meyerhoff, Dieter J. ; Lenkinski, Robert E. ; Gonzalez, R. Gilberto ; Navia, Bradford A. / A multi-center 1H MRS study of the AIDS dementia complex : Validation and preliminary analysis. In: Journal of magnetic resonance imaging : JMRI. 2003 ; Vol. 17, No. 6. pp. 625-633.
@article{e2d5915de7c74ce8a73ce5104007ca5b,
title = "A multi-center 1H MRS study of the AIDS dementia complex: Validation and preliminary analysis",
abstract = "Purpose: To demonstrate the technical feasibility and reliability of a multi-center study characterizing regional levels of the brain metabolite ratios choline (Cho)/creatine (Cr) and myoinositol (MI)/Cr, markers of glial cell activity, and N-acetyl aspartate (NAA)/Cr, a marker of mature neurons, in subjects with AIDS dementia complex (ADC). Materials and Methods: Using an automated protocol (GE PROBE-P), short echo time spectra (TE = 35 msec) were obtained at eight sites from uniformly prepared phantoms and from three brain regions (frontal white matter, basal ganglia, and parietal cortex) of normal volunteers and ADC and HIV-negative subjects. Results: A random-effects model of the phantom and volunteer data showed no significant inter-site differences. Feasibility of a multi-center study was further validated by detection of significant differences between the metabolite ratios of ADC subjects and HIV-negative controls. ADC subjects exhibited significantly higher Cho/Cr and MI/Cr in the basal ganglia and significantly reduced NAA/Cr and significantly higher MI/Cr in the frontal white matter. These results are consistent with the predominantly subcortical distribution of the pathologic abnormalities associated with ADC. Conclusion: This is the first study to ascertain and validate the reliability and reproducibility of a short echo time 1HMRS acquisition sequence from multiple brain regions in a multi-center setting. It should now be possible to examine the regional effects of HIV infection in the brain in a large number of subjects and to study the metabolic effects of new therapies for the treatment of ADC in a clinical trial setting.",
keywords = "AIDS dementia complex (ADC), HIV infection, MRS, Neuroimaging, Spectroscopy",
author = "Lee, {Patricia Lani} and Constantin Yiannoutsos and Thomas Ernst and Linda Chang and Marra, {Christina M.} and Jarvik, {Jeffrey G.} and Richards, {Todd L.} and Kwok, {Edmund W.} and Kolson, {Dennis L.} and David Simpson and Tang, {Cheuk Y.} and Giovanni Schifitto and Ketonen, {Leena M.} and Meyerhoff, {Dieter J.} and Lenkinski, {Robert E.} and Gonzalez, {R. Gilberto} and Navia, {Bradford A.}",
year = "2003",
month = "6",
day = "1",
doi = "10.1002/jmri.10295",
language = "English (US)",
volume = "17",
pages = "625--633",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - A multi-center 1H MRS study of the AIDS dementia complex

T2 - Validation and preliminary analysis

AU - Lee, Patricia Lani

AU - Yiannoutsos, Constantin

AU - Ernst, Thomas

AU - Chang, Linda

AU - Marra, Christina M.

AU - Jarvik, Jeffrey G.

AU - Richards, Todd L.

AU - Kwok, Edmund W.

AU - Kolson, Dennis L.

AU - Simpson, David

AU - Tang, Cheuk Y.

AU - Schifitto, Giovanni

AU - Ketonen, Leena M.

AU - Meyerhoff, Dieter J.

AU - Lenkinski, Robert E.

AU - Gonzalez, R. Gilberto

AU - Navia, Bradford A.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Purpose: To demonstrate the technical feasibility and reliability of a multi-center study characterizing regional levels of the brain metabolite ratios choline (Cho)/creatine (Cr) and myoinositol (MI)/Cr, markers of glial cell activity, and N-acetyl aspartate (NAA)/Cr, a marker of mature neurons, in subjects with AIDS dementia complex (ADC). Materials and Methods: Using an automated protocol (GE PROBE-P), short echo time spectra (TE = 35 msec) were obtained at eight sites from uniformly prepared phantoms and from three brain regions (frontal white matter, basal ganglia, and parietal cortex) of normal volunteers and ADC and HIV-negative subjects. Results: A random-effects model of the phantom and volunteer data showed no significant inter-site differences. Feasibility of a multi-center study was further validated by detection of significant differences between the metabolite ratios of ADC subjects and HIV-negative controls. ADC subjects exhibited significantly higher Cho/Cr and MI/Cr in the basal ganglia and significantly reduced NAA/Cr and significantly higher MI/Cr in the frontal white matter. These results are consistent with the predominantly subcortical distribution of the pathologic abnormalities associated with ADC. Conclusion: This is the first study to ascertain and validate the reliability and reproducibility of a short echo time 1HMRS acquisition sequence from multiple brain regions in a multi-center setting. It should now be possible to examine the regional effects of HIV infection in the brain in a large number of subjects and to study the metabolic effects of new therapies for the treatment of ADC in a clinical trial setting.

AB - Purpose: To demonstrate the technical feasibility and reliability of a multi-center study characterizing regional levels of the brain metabolite ratios choline (Cho)/creatine (Cr) and myoinositol (MI)/Cr, markers of glial cell activity, and N-acetyl aspartate (NAA)/Cr, a marker of mature neurons, in subjects with AIDS dementia complex (ADC). Materials and Methods: Using an automated protocol (GE PROBE-P), short echo time spectra (TE = 35 msec) were obtained at eight sites from uniformly prepared phantoms and from three brain regions (frontal white matter, basal ganglia, and parietal cortex) of normal volunteers and ADC and HIV-negative subjects. Results: A random-effects model of the phantom and volunteer data showed no significant inter-site differences. Feasibility of a multi-center study was further validated by detection of significant differences between the metabolite ratios of ADC subjects and HIV-negative controls. ADC subjects exhibited significantly higher Cho/Cr and MI/Cr in the basal ganglia and significantly reduced NAA/Cr and significantly higher MI/Cr in the frontal white matter. These results are consistent with the predominantly subcortical distribution of the pathologic abnormalities associated with ADC. Conclusion: This is the first study to ascertain and validate the reliability and reproducibility of a short echo time 1HMRS acquisition sequence from multiple brain regions in a multi-center setting. It should now be possible to examine the regional effects of HIV infection in the brain in a large number of subjects and to study the metabolic effects of new therapies for the treatment of ADC in a clinical trial setting.

KW - AIDS dementia complex (ADC)

KW - HIV infection

KW - MRS

KW - Neuroimaging

KW - Spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=0038727282&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038727282&partnerID=8YFLogxK

U2 - 10.1002/jmri.10295

DO - 10.1002/jmri.10295

M3 - Article

C2 - 12766890

AN - SCOPUS:0038727282

VL - 17

SP - 625

EP - 633

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 6

ER -