Abstract
Purpose: To demonstrate the technical feasibility and reliability of a multi-center study characterizing regional levels of the brain metabolite ratios choline (Cho)/creatine (Cr) and myoinositol (MI)/Cr, markers of glial cell activity, and N-acetyl aspartate (NAA)/Cr, a marker of mature neurons, in subjects with AIDS dementia complex (ADC). Materials and Methods: Using an automated protocol (GE PROBE-P), short echo time spectra (TE = 35 msec) were obtained at eight sites from uniformly prepared phantoms and from three brain regions (frontal white matter, basal ganglia, and parietal cortex) of normal volunteers and ADC and HIV-negative subjects. Results: A random-effects model of the phantom and volunteer data showed no significant inter-site differences. Feasibility of a multi-center study was further validated by detection of significant differences between the metabolite ratios of ADC subjects and HIV-negative controls. ADC subjects exhibited significantly higher Cho/Cr and MI/Cr in the basal ganglia and significantly reduced NAA/Cr and significantly higher MI/Cr in the frontal white matter. These results are consistent with the predominantly subcortical distribution of the pathologic abnormalities associated with ADC. Conclusion: This is the first study to ascertain and validate the reliability and reproducibility of a short echo time 1HMRS acquisition sequence from multiple brain regions in a multi-center setting. It should now be possible to examine the regional effects of HIV infection in the brain in a large number of subjects and to study the metabolic effects of new therapies for the treatment of ADC in a clinical trial setting.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 625-633 |
| Number of pages | 9 |
| Journal | Journal of magnetic resonance imaging : JMRI |
| Volume | 17 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2003 |
| Externally published | Yes |
Fingerprint
Keywords
- AIDS dementia complex (ADC)
- HIV infection
- MRS
- Neuroimaging
- Spectroscopy
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
A multi-center 1H MRS study of the AIDS dementia complex : Validation and preliminary analysis. / Lee, Patricia Lani; Yiannoutsos, Constantin; Ernst, Thomas; Chang, Linda; Marra, Christina M.; Jarvik, Jeffrey G.; Richards, Todd L.; Kwok, Edmund W.; Kolson, Dennis L.; Simpson, David; Tang, Cheuk Y.; Schifitto, Giovanni; Ketonen, Leena M.; Meyerhoff, Dieter J.; Lenkinski, Robert E.; Gonzalez, R. Gilberto; Navia, Bradford A.
In: Journal of magnetic resonance imaging : JMRI, Vol. 17, No. 6, 01.06.2003, p. 625-633.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A multi-center 1H MRS study of the AIDS dementia complex
T2 - Validation and preliminary analysis
AU - Lee, Patricia Lani
AU - Yiannoutsos, Constantin
AU - Ernst, Thomas
AU - Chang, Linda
AU - Marra, Christina M.
AU - Jarvik, Jeffrey G.
AU - Richards, Todd L.
AU - Kwok, Edmund W.
AU - Kolson, Dennis L.
AU - Simpson, David
AU - Tang, Cheuk Y.
AU - Schifitto, Giovanni
AU - Ketonen, Leena M.
AU - Meyerhoff, Dieter J.
AU - Lenkinski, Robert E.
AU - Gonzalez, R. Gilberto
AU - Navia, Bradford A.
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Purpose: To demonstrate the technical feasibility and reliability of a multi-center study characterizing regional levels of the brain metabolite ratios choline (Cho)/creatine (Cr) and myoinositol (MI)/Cr, markers of glial cell activity, and N-acetyl aspartate (NAA)/Cr, a marker of mature neurons, in subjects with AIDS dementia complex (ADC). Materials and Methods: Using an automated protocol (GE PROBE-P), short echo time spectra (TE = 35 msec) were obtained at eight sites from uniformly prepared phantoms and from three brain regions (frontal white matter, basal ganglia, and parietal cortex) of normal volunteers and ADC and HIV-negative subjects. Results: A random-effects model of the phantom and volunteer data showed no significant inter-site differences. Feasibility of a multi-center study was further validated by detection of significant differences between the metabolite ratios of ADC subjects and HIV-negative controls. ADC subjects exhibited significantly higher Cho/Cr and MI/Cr in the basal ganglia and significantly reduced NAA/Cr and significantly higher MI/Cr in the frontal white matter. These results are consistent with the predominantly subcortical distribution of the pathologic abnormalities associated with ADC. Conclusion: This is the first study to ascertain and validate the reliability and reproducibility of a short echo time 1HMRS acquisition sequence from multiple brain regions in a multi-center setting. It should now be possible to examine the regional effects of HIV infection in the brain in a large number of subjects and to study the metabolic effects of new therapies for the treatment of ADC in a clinical trial setting.
AB - Purpose: To demonstrate the technical feasibility and reliability of a multi-center study characterizing regional levels of the brain metabolite ratios choline (Cho)/creatine (Cr) and myoinositol (MI)/Cr, markers of glial cell activity, and N-acetyl aspartate (NAA)/Cr, a marker of mature neurons, in subjects with AIDS dementia complex (ADC). Materials and Methods: Using an automated protocol (GE PROBE-P), short echo time spectra (TE = 35 msec) were obtained at eight sites from uniformly prepared phantoms and from three brain regions (frontal white matter, basal ganglia, and parietal cortex) of normal volunteers and ADC and HIV-negative subjects. Results: A random-effects model of the phantom and volunteer data showed no significant inter-site differences. Feasibility of a multi-center study was further validated by detection of significant differences between the metabolite ratios of ADC subjects and HIV-negative controls. ADC subjects exhibited significantly higher Cho/Cr and MI/Cr in the basal ganglia and significantly reduced NAA/Cr and significantly higher MI/Cr in the frontal white matter. These results are consistent with the predominantly subcortical distribution of the pathologic abnormalities associated with ADC. Conclusion: This is the first study to ascertain and validate the reliability and reproducibility of a short echo time 1HMRS acquisition sequence from multiple brain regions in a multi-center setting. It should now be possible to examine the regional effects of HIV infection in the brain in a large number of subjects and to study the metabolic effects of new therapies for the treatment of ADC in a clinical trial setting.
KW - AIDS dementia complex (ADC)
KW - HIV infection
KW - MRS
KW - Neuroimaging
KW - Spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=0038727282&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038727282&partnerID=8YFLogxK
U2 - 10.1002/jmri.10295
DO - 10.1002/jmri.10295
M3 - Article
C2 - 12766890
AN - SCOPUS:0038727282
VL - 17
SP - 625
EP - 633
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
SN - 1053-1807
IS - 6
ER -