A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies

Michael A. Nalls, Raquel Duran, Grisel Lopez, Marzena Kurzawa-Akanbi, Ian G. McKeith, Patrick F. Chinnery, Christopher M. Morris, Jessie Theuns, David Crosiers, Patrick Cras, Sebastiaan Engelborghs, Peter Paul De Deyn, Christine Van Broeckhoven, David M A Mann, Julie Snowden, Stuart Pickering-Brown, Nicola Halliwell, Yvonne Davidson, Linda Gibbons, Jenny HarrisUna Marie Sheerin, Jose Bras, John Hardy, Lorraine Clark, Karen Marder, Lawrence S. Honig, Daniela Berg, Walter Maetzler, Kathrin Brockmann, Thomas Gasser, Fabiana Novellino, Aldo Quattrone, Grazia Annesi, Elvira Valeria De Marco, Ekaterina Rogaeva, Mario Masellis, Sandra E. Black, Juan M. Bilbao, Tatiana Foroud, Bernardino Ghetti, William C. Nichols, Nathan Pankratz, Glenda Halliday, Suzanne Lesage, Stephan Klebe, Alexandra Durr, Charles Duyckaerts, Alexis Brice, Benoit I. Giasson, John Q. Trojanowski, Howard I. Hurtig, Nahid Tayebi, Claudia Landazabal, Melanie A. Knight, Margaux Keller, Andrew B. Singleton, Tyra G. Wolfsberg, Ellen Sidransky

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

Importance: While mutations in glucocerebrosidase (GBA1) are associated with an increased risk for Parkinson disease (PD), it is important to establish whether such mutations are also a common risk factor for other Lewy body disorders. Objective: To establish whether GBA1 mutations are a risk factor for dementia with Lewy bodies (DLB). Design: Wecompared genotype data on patients and controls from 11 centers. Data concerning demographics, age at onset, disease duration, and clinical and pathological features were collected when available. We conducted pooled analyses using logistic regression to investigate GBA1 mutation carrier status as predicting DLB or PD with dementia status, using common control subjects as a reference group. Random-effects meta-analyses were conducted to account for additional heterogeneity. Setting: Eleven centers from sites around the world performing genotyping. Participants: Seven hundred twenty-one cases met diagnostic criteria for DLB and 151 had PD with dementia. We compared these cases with 1962 controls from the same centers matched for age, sex, and ethnicity. Main Outcome Measures: Frequency of GBA1 mutations in cases and controls. Results: We found a significant association between GBA1 mutation carrier status and DLB, with an odds ratio of 8.28 (95% CI, 4.78-14.88). The odds ratio for PD with dementia was 6.48 (95% CI, 2.53-15.37). The mean age at diagnosis of DLB was earlier in GBA1 mutation carriers than in noncarriers (63.5 vs 68.9 years; P < .001), with higher disease severity scores. Conclusions and Relevance: Mutations in GBA1 are a significant risk factor for DLB. GBA1 mutations likely play an even larger role in the genetic etiology of DLB than in PD, providing insight into the role of glucocerebrosidase in Lewy body disease.

Original languageEnglish
Pages (from-to)727-735
Number of pages9
JournalJAMA Neurology
Volume70
Issue number6
DOIs
StatePublished - 2013

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Glucosylceramidase
Lewy Body Disease
Multicenter Studies
Mutation
Parkinson Disease
Dementia
Odds Ratio
Lewy Bodies
Mutation Rate
Age of Onset
Meta-Analysis
Logistic Models
Genotype
Demography
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Nalls, M. A., Duran, R., Lopez, G., Kurzawa-Akanbi, M., McKeith, I. G., Chinnery, P. F., ... Sidransky, E. (2013). A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies. JAMA Neurology, 70(6), 727-735. https://doi.org/10.1001/jamaneurol.2013.1925

A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies. / Nalls, Michael A.; Duran, Raquel; Lopez, Grisel; Kurzawa-Akanbi, Marzena; McKeith, Ian G.; Chinnery, Patrick F.; Morris, Christopher M.; Theuns, Jessie; Crosiers, David; Cras, Patrick; Engelborghs, Sebastiaan; De Deyn, Peter Paul; Van Broeckhoven, Christine; Mann, David M A; Snowden, Julie; Pickering-Brown, Stuart; Halliwell, Nicola; Davidson, Yvonne; Gibbons, Linda; Harris, Jenny; Sheerin, Una Marie; Bras, Jose; Hardy, John; Clark, Lorraine; Marder, Karen; Honig, Lawrence S.; Berg, Daniela; Maetzler, Walter; Brockmann, Kathrin; Gasser, Thomas; Novellino, Fabiana; Quattrone, Aldo; Annesi, Grazia; De Marco, Elvira Valeria; Rogaeva, Ekaterina; Masellis, Mario; Black, Sandra E.; Bilbao, Juan M.; Foroud, Tatiana; Ghetti, Bernardino; Nichols, William C.; Pankratz, Nathan; Halliday, Glenda; Lesage, Suzanne; Klebe, Stephan; Durr, Alexandra; Duyckaerts, Charles; Brice, Alexis; Giasson, Benoit I.; Trojanowski, John Q.; Hurtig, Howard I.; Tayebi, Nahid; Landazabal, Claudia; Knight, Melanie A.; Keller, Margaux; Singleton, Andrew B.; Wolfsberg, Tyra G.; Sidransky, Ellen.

In: JAMA Neurology, Vol. 70, No. 6, 2013, p. 727-735.

Research output: Contribution to journalArticle

Nalls, MA, Duran, R, Lopez, G, Kurzawa-Akanbi, M, McKeith, IG, Chinnery, PF, Morris, CM, Theuns, J, Crosiers, D, Cras, P, Engelborghs, S, De Deyn, PP, Van Broeckhoven, C, Mann, DMA, Snowden, J, Pickering-Brown, S, Halliwell, N, Davidson, Y, Gibbons, L, Harris, J, Sheerin, UM, Bras, J, Hardy, J, Clark, L, Marder, K, Honig, LS, Berg, D, Maetzler, W, Brockmann, K, Gasser, T, Novellino, F, Quattrone, A, Annesi, G, De Marco, EV, Rogaeva, E, Masellis, M, Black, SE, Bilbao, JM, Foroud, T, Ghetti, B, Nichols, WC, Pankratz, N, Halliday, G, Lesage, S, Klebe, S, Durr, A, Duyckaerts, C, Brice, A, Giasson, BI, Trojanowski, JQ, Hurtig, HI, Tayebi, N, Landazabal, C, Knight, MA, Keller, M, Singleton, AB, Wolfsberg, TG & Sidransky, E 2013, 'A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies', JAMA Neurology, vol. 70, no. 6, pp. 727-735. https://doi.org/10.1001/jamaneurol.2013.1925
Nalls MA, Duran R, Lopez G, Kurzawa-Akanbi M, McKeith IG, Chinnery PF et al. A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies. JAMA Neurology. 2013;70(6):727-735. https://doi.org/10.1001/jamaneurol.2013.1925
Nalls, Michael A. ; Duran, Raquel ; Lopez, Grisel ; Kurzawa-Akanbi, Marzena ; McKeith, Ian G. ; Chinnery, Patrick F. ; Morris, Christopher M. ; Theuns, Jessie ; Crosiers, David ; Cras, Patrick ; Engelborghs, Sebastiaan ; De Deyn, Peter Paul ; Van Broeckhoven, Christine ; Mann, David M A ; Snowden, Julie ; Pickering-Brown, Stuart ; Halliwell, Nicola ; Davidson, Yvonne ; Gibbons, Linda ; Harris, Jenny ; Sheerin, Una Marie ; Bras, Jose ; Hardy, John ; Clark, Lorraine ; Marder, Karen ; Honig, Lawrence S. ; Berg, Daniela ; Maetzler, Walter ; Brockmann, Kathrin ; Gasser, Thomas ; Novellino, Fabiana ; Quattrone, Aldo ; Annesi, Grazia ; De Marco, Elvira Valeria ; Rogaeva, Ekaterina ; Masellis, Mario ; Black, Sandra E. ; Bilbao, Juan M. ; Foroud, Tatiana ; Ghetti, Bernardino ; Nichols, William C. ; Pankratz, Nathan ; Halliday, Glenda ; Lesage, Suzanne ; Klebe, Stephan ; Durr, Alexandra ; Duyckaerts, Charles ; Brice, Alexis ; Giasson, Benoit I. ; Trojanowski, John Q. ; Hurtig, Howard I. ; Tayebi, Nahid ; Landazabal, Claudia ; Knight, Melanie A. ; Keller, Margaux ; Singleton, Andrew B. ; Wolfsberg, Tyra G. ; Sidransky, Ellen. / A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies. In: JAMA Neurology. 2013 ; Vol. 70, No. 6. pp. 727-735.
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title = "A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies",
abstract = "Importance: While mutations in glucocerebrosidase (GBA1) are associated with an increased risk for Parkinson disease (PD), it is important to establish whether such mutations are also a common risk factor for other Lewy body disorders. Objective: To establish whether GBA1 mutations are a risk factor for dementia with Lewy bodies (DLB). Design: Wecompared genotype data on patients and controls from 11 centers. Data concerning demographics, age at onset, disease duration, and clinical and pathological features were collected when available. We conducted pooled analyses using logistic regression to investigate GBA1 mutation carrier status as predicting DLB or PD with dementia status, using common control subjects as a reference group. Random-effects meta-analyses were conducted to account for additional heterogeneity. Setting: Eleven centers from sites around the world performing genotyping. Participants: Seven hundred twenty-one cases met diagnostic criteria for DLB and 151 had PD with dementia. We compared these cases with 1962 controls from the same centers matched for age, sex, and ethnicity. Main Outcome Measures: Frequency of GBA1 mutations in cases and controls. Results: We found a significant association between GBA1 mutation carrier status and DLB, with an odds ratio of 8.28 (95{\%} CI, 4.78-14.88). The odds ratio for PD with dementia was 6.48 (95{\%} CI, 2.53-15.37). The mean age at diagnosis of DLB was earlier in GBA1 mutation carriers than in noncarriers (63.5 vs 68.9 years; P < .001), with higher disease severity scores. Conclusions and Relevance: Mutations in GBA1 are a significant risk factor for DLB. GBA1 mutations likely play an even larger role in the genetic etiology of DLB than in PD, providing insight into the role of glucocerebrosidase in Lewy body disease.",
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T1 - A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies

AU - Nalls, Michael A.

AU - Duran, Raquel

AU - Lopez, Grisel

AU - Kurzawa-Akanbi, Marzena

AU - McKeith, Ian G.

AU - Chinnery, Patrick F.

AU - Morris, Christopher M.

AU - Theuns, Jessie

AU - Crosiers, David

AU - Cras, Patrick

AU - Engelborghs, Sebastiaan

AU - De Deyn, Peter Paul

AU - Van Broeckhoven, Christine

AU - Mann, David M A

AU - Snowden, Julie

AU - Pickering-Brown, Stuart

AU - Halliwell, Nicola

AU - Davidson, Yvonne

AU - Gibbons, Linda

AU - Harris, Jenny

AU - Sheerin, Una Marie

AU - Bras, Jose

AU - Hardy, John

AU - Clark, Lorraine

AU - Marder, Karen

AU - Honig, Lawrence S.

AU - Berg, Daniela

AU - Maetzler, Walter

AU - Brockmann, Kathrin

AU - Gasser, Thomas

AU - Novellino, Fabiana

AU - Quattrone, Aldo

AU - Annesi, Grazia

AU - De Marco, Elvira Valeria

AU - Rogaeva, Ekaterina

AU - Masellis, Mario

AU - Black, Sandra E.

AU - Bilbao, Juan M.

AU - Foroud, Tatiana

AU - Ghetti, Bernardino

AU - Nichols, William C.

AU - Pankratz, Nathan

AU - Halliday, Glenda

AU - Lesage, Suzanne

AU - Klebe, Stephan

AU - Durr, Alexandra

AU - Duyckaerts, Charles

AU - Brice, Alexis

AU - Giasson, Benoit I.

AU - Trojanowski, John Q.

AU - Hurtig, Howard I.

AU - Tayebi, Nahid

AU - Landazabal, Claudia

AU - Knight, Melanie A.

AU - Keller, Margaux

AU - Singleton, Andrew B.

AU - Wolfsberg, Tyra G.

AU - Sidransky, Ellen

PY - 2013

Y1 - 2013

N2 - Importance: While mutations in glucocerebrosidase (GBA1) are associated with an increased risk for Parkinson disease (PD), it is important to establish whether such mutations are also a common risk factor for other Lewy body disorders. Objective: To establish whether GBA1 mutations are a risk factor for dementia with Lewy bodies (DLB). Design: Wecompared genotype data on patients and controls from 11 centers. Data concerning demographics, age at onset, disease duration, and clinical and pathological features were collected when available. We conducted pooled analyses using logistic regression to investigate GBA1 mutation carrier status as predicting DLB or PD with dementia status, using common control subjects as a reference group. Random-effects meta-analyses were conducted to account for additional heterogeneity. Setting: Eleven centers from sites around the world performing genotyping. Participants: Seven hundred twenty-one cases met diagnostic criteria for DLB and 151 had PD with dementia. We compared these cases with 1962 controls from the same centers matched for age, sex, and ethnicity. Main Outcome Measures: Frequency of GBA1 mutations in cases and controls. Results: We found a significant association between GBA1 mutation carrier status and DLB, with an odds ratio of 8.28 (95% CI, 4.78-14.88). The odds ratio for PD with dementia was 6.48 (95% CI, 2.53-15.37). The mean age at diagnosis of DLB was earlier in GBA1 mutation carriers than in noncarriers (63.5 vs 68.9 years; P < .001), with higher disease severity scores. Conclusions and Relevance: Mutations in GBA1 are a significant risk factor for DLB. GBA1 mutations likely play an even larger role in the genetic etiology of DLB than in PD, providing insight into the role of glucocerebrosidase in Lewy body disease.

AB - Importance: While mutations in glucocerebrosidase (GBA1) are associated with an increased risk for Parkinson disease (PD), it is important to establish whether such mutations are also a common risk factor for other Lewy body disorders. Objective: To establish whether GBA1 mutations are a risk factor for dementia with Lewy bodies (DLB). Design: Wecompared genotype data on patients and controls from 11 centers. Data concerning demographics, age at onset, disease duration, and clinical and pathological features were collected when available. We conducted pooled analyses using logistic regression to investigate GBA1 mutation carrier status as predicting DLB or PD with dementia status, using common control subjects as a reference group. Random-effects meta-analyses were conducted to account for additional heterogeneity. Setting: Eleven centers from sites around the world performing genotyping. Participants: Seven hundred twenty-one cases met diagnostic criteria for DLB and 151 had PD with dementia. We compared these cases with 1962 controls from the same centers matched for age, sex, and ethnicity. Main Outcome Measures: Frequency of GBA1 mutations in cases and controls. Results: We found a significant association between GBA1 mutation carrier status and DLB, with an odds ratio of 8.28 (95% CI, 4.78-14.88). The odds ratio for PD with dementia was 6.48 (95% CI, 2.53-15.37). The mean age at diagnosis of DLB was earlier in GBA1 mutation carriers than in noncarriers (63.5 vs 68.9 years; P < .001), with higher disease severity scores. Conclusions and Relevance: Mutations in GBA1 are a significant risk factor for DLB. GBA1 mutations likely play an even larger role in the genetic etiology of DLB than in PD, providing insight into the role of glucocerebrosidase in Lewy body disease.

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