A multigenic program mediating breast cancer metastasis to bone

Yibin Kang, Peter M. Siegel, Weiping Shu, Maria Drobnjak, Sanna M. Kakonen, Carlos Cordón-Cardo, Theresa Guise, Joan Massagué

Research output: Contribution to journalArticle

1715 Citations (Scopus)

Abstract

We investigated the molecular basis for osteolytic bone metastasis by selecting human breast cancer cell line subpopulations with elevated metastatic activity and functionally validating genes that are overexpressed in these cells. These genes act cooperatively to cause osteolytic metastasis, and most of them encode secreted and cell surface proteins. Two of these genes, interleukin-11 and CTGF, encode osteolytic and angiogenic factors whose expression is further increased by the prometastatic cytokine TGFβ. Overexpression of this bone metastasis gene set is superimposed on a poor-prognosis gene expression signature already present in the parental breast cancer population, suggesting that metastasis requires a set of functions beyond those underlying the emergence of the primary tumor.

Original languageEnglish (US)
Pages (from-to)537-549
Number of pages13
JournalCancer Cell
Volume3
Issue number6
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

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Breast Neoplasms
Neoplasm Metastasis
Bone and Bones
Genes
Interleukin-11
Angiogenesis Inducing Agents
Transcriptome
Membrane Proteins
Cytokines
Cell Line
Population
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Kakonen, S. M., Cordón-Cardo, C., ... Massagué, J. (2003). A multigenic program mediating breast cancer metastasis to bone. Cancer Cell, 3(6), 537-549. https://doi.org/10.1016/S1535-6108(03)00132-6

A multigenic program mediating breast cancer metastasis to bone. / Kang, Yibin; Siegel, Peter M.; Shu, Weiping; Drobnjak, Maria; Kakonen, Sanna M.; Cordón-Cardo, Carlos; Guise, Theresa; Massagué, Joan.

In: Cancer Cell, Vol. 3, No. 6, 01.06.2003, p. 537-549.

Research output: Contribution to journalArticle

Kang, Y, Siegel, PM, Shu, W, Drobnjak, M, Kakonen, SM, Cordón-Cardo, C, Guise, T & Massagué, J 2003, 'A multigenic program mediating breast cancer metastasis to bone', Cancer Cell, vol. 3, no. 6, pp. 537-549. https://doi.org/10.1016/S1535-6108(03)00132-6
Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordón-Cardo C et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell. 2003 Jun 1;3(6):537-549. https://doi.org/10.1016/S1535-6108(03)00132-6
Kang, Yibin ; Siegel, Peter M. ; Shu, Weiping ; Drobnjak, Maria ; Kakonen, Sanna M. ; Cordón-Cardo, Carlos ; Guise, Theresa ; Massagué, Joan. / A multigenic program mediating breast cancer metastasis to bone. In: Cancer Cell. 2003 ; Vol. 3, No. 6. pp. 537-549.
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