A Multiprotein Complex That Interacts with RNA Polymerase II Elongator

Yang Li, Yuichiro Takagi, Yiwei Jiang, Masao Tokunaga, Hediye Erdjument-Bromage, Paul Tempst, Roger D. Kornberg

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

A three-subunit Hap complex that interacts with the RNA polymerase II Elongator was isolated from yeast. Deletions of genes for two Hap subunits, HAP1 and HAP3, confer pGKL killer-insensitive and weak Elongator phenotypes. Preferential interaction of the Hap complex with free rather than RNA polymerase II-associated Elongator suggests a role in the regulation of Elongator activity.

Original languageEnglish (US)
Pages (from-to)29628-29631
Number of pages4
JournalJournal of Biological Chemistry
Volume276
Issue number32
DOIs
StatePublished - Aug 10 2001
Externally publishedYes

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Multiprotein Complexes
RNA Polymerase II
Gene Deletion
Yeast
Genes
Yeasts
Phenotype

ASJC Scopus subject areas

  • Biochemistry

Cite this

Li, Y., Takagi, Y., Jiang, Y., Tokunaga, M., Erdjument-Bromage, H., Tempst, P., & Kornberg, R. D. (2001). A Multiprotein Complex That Interacts with RNA Polymerase II Elongator. Journal of Biological Chemistry, 276(32), 29628-29631. https://doi.org/10.1074/jbc.C100274200

A Multiprotein Complex That Interacts with RNA Polymerase II Elongator. / Li, Yang; Takagi, Yuichiro; Jiang, Yiwei; Tokunaga, Masao; Erdjument-Bromage, Hediye; Tempst, Paul; Kornberg, Roger D.

In: Journal of Biological Chemistry, Vol. 276, No. 32, 10.08.2001, p. 29628-29631.

Research output: Contribution to journalArticle

Li, Y, Takagi, Y, Jiang, Y, Tokunaga, M, Erdjument-Bromage, H, Tempst, P & Kornberg, RD 2001, 'A Multiprotein Complex That Interacts with RNA Polymerase II Elongator', Journal of Biological Chemistry, vol. 276, no. 32, pp. 29628-29631. https://doi.org/10.1074/jbc.C100274200
Li Y, Takagi Y, Jiang Y, Tokunaga M, Erdjument-Bromage H, Tempst P et al. A Multiprotein Complex That Interacts with RNA Polymerase II Elongator. Journal of Biological Chemistry. 2001 Aug 10;276(32):29628-29631. https://doi.org/10.1074/jbc.C100274200
Li, Yang ; Takagi, Yuichiro ; Jiang, Yiwei ; Tokunaga, Masao ; Erdjument-Bromage, Hediye ; Tempst, Paul ; Kornberg, Roger D. / A Multiprotein Complex That Interacts with RNA Polymerase II Elongator. In: Journal of Biological Chemistry. 2001 ; Vol. 276, No. 32. pp. 29628-29631.
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