A Multiprotein Complex That Interacts with RNA Polymerase II Elongator

Yang Li, Yuichiro Takagi, Yiwei Jiang, Masao Tokunaga, Hediye Erdjument-Bromage, Paul Tempst, Roger D. Kornberg

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

A three-subunit Hap complex that interacts with the RNA polymerase II Elongator was isolated from yeast. Deletions of genes for two Hap subunits, HAP1 and HAP3, confer pGKL killer-insensitive and weak Elongator phenotypes. Preferential interaction of the Hap complex with free rather than RNA polymerase II-associated Elongator suggests a role in the regulation of Elongator activity.

Original languageEnglish (US)
Pages (from-to)29628-29631
Number of pages4
JournalJournal of Biological Chemistry
Volume276
Issue number32
DOIs
StatePublished - Aug 10 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Li, Y., Takagi, Y., Jiang, Y., Tokunaga, M., Erdjument-Bromage, H., Tempst, P., & Kornberg, R. D. (2001). A Multiprotein Complex That Interacts with RNA Polymerase II Elongator. Journal of Biological Chemistry, 276(32), 29628-29631. https://doi.org/10.1074/jbc.C100274200