A multiscale model of venous thrombus formation with surface-mediated control of blood coagulation cascade

Zhiliang Xu, Joshua Lioi, Jian Mu, Malgorzata Kamocka, Xiaomin Liu, Danny Z. Chen, Elliot Rosen, Mark Alber

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

A combination of the extended multiscale model, new image processing algorithms, and biological experiments is used for studying the role of Factor VII (FVII) in venous thrombus formation. A detailed submodel of the tissue factor pathway of blood coagulation is introduced within the framework of the multiscale model to provide a detailed description of coagulation cascade. Surface reactions of the extrinsic coagulation pathway on membranes of platelets are studied under different flow conditions. It is shown that low levels of FVII in blood result in a significant delay in thrombin production, demonstrating that FVII plays an active role in promoting thrombus development at an early stage.

Original languageEnglish
Pages (from-to)1723-1732
Number of pages10
JournalBiophysical Journal
Volume98
Issue number9
DOIs
StatePublished - May 5 2010

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Factor VII
Blood Coagulation
Thrombosis
Thromboplastin
Thrombin
Blood Platelets
Membranes

ASJC Scopus subject areas

  • Biophysics

Cite this

A multiscale model of venous thrombus formation with surface-mediated control of blood coagulation cascade. / Xu, Zhiliang; Lioi, Joshua; Mu, Jian; Kamocka, Malgorzata; Liu, Xiaomin; Chen, Danny Z.; Rosen, Elliot; Alber, Mark.

In: Biophysical Journal, Vol. 98, No. 9, 05.05.2010, p. 1723-1732.

Research output: Contribution to journalArticle

Xu, Zhiliang ; Lioi, Joshua ; Mu, Jian ; Kamocka, Malgorzata ; Liu, Xiaomin ; Chen, Danny Z. ; Rosen, Elliot ; Alber, Mark. / A multiscale model of venous thrombus formation with surface-mediated control of blood coagulation cascade. In: Biophysical Journal. 2010 ; Vol. 98, No. 9. pp. 1723-1732.
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