A murine model of inflammatory bone disease

T. A. Hentunen, S. J. Choi, B. F. Boyce, M. R. Dallas, S. L. Dallas, G. L. Shen-Ong, G. D. Roodman

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

We have recently reported the identification of a new recessive mutation on murine chromosome 18 that results in tail kinks and deformity in the lower extremities of mice. Preliminary examination of the bones of these mice showed that there are abnormalities present that resembled chronic recurrent multifocal osteomyelitis. Accordingly, this new mutation was named 'CMO.' In this report, we describe the histology of bones in CMO mice, as well as the capacity of the bone marrow cells from these animals to form osteoclasts (OCLs). In addition, we tested conditioned media from nonadherent marrow cells and total marrow cells from CMO mice for their capacity to induce OCL formation in normal murine marrow cultures. These studies demonstrated that the bone disease in these animals is inflammatory in nature, and a soluble factor(s) that is not IL-1α, IL-6 or TNF-α is released by marrow cells from CMO animals and enhances OCL formation in normal murine marrow cultures. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalBone
Volume26
Issue number2
DOIs
StatePublished - Feb 1 2000
Externally publishedYes

Keywords

  • Bone resorption
  • Cytokines
  • Inflammatory bone disease
  • Osteomyelitis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

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    Hentunen, T. A., Choi, S. J., Boyce, B. F., Dallas, M. R., Dallas, S. L., Shen-Ong, G. L., & Roodman, G. D. (2000). A murine model of inflammatory bone disease. Bone, 26(2), 183-188. https://doi.org/10.1016/S8756-3282(99)00247-1