A murine model of inflammatory bone disease

T. A. Hentunen, S. J. Choi, B. F. Boyce, M. R. Dallas, S. L. Dallas, G. L. Shen-Ong, G. David Roodman

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We have recently reported the identification of a new recessive mutation on murine chromosome 18 that results in tail kinks and deformity in the lower extremities of mice. Preliminary examination of the bones of these mice showed that there are abnormalities present that resembled chronic recurrent multifocal osteomyelitis. Accordingly, this new mutation was named 'CMO.' In this report, we describe the histology of bones in CMO mice, as well as the capacity of the bone marrow cells from these animals to form osteoclasts (OCLs). In addition, we tested conditioned media from nonadherent marrow cells and total marrow cells from CMO mice for their capacity to induce OCL formation in normal murine marrow cultures. These studies demonstrated that the bone disease in these animals is inflammatory in nature, and a soluble factor(s) that is not IL-1α, IL-6 or TNF-α is released by marrow cells from CMO animals and enhances OCL formation in normal murine marrow cultures. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalBone
Volume26
Issue number2
DOIs
StatePublished - Feb 2000
Externally publishedYes

Fingerprint

Bone Diseases
Bone Marrow
Osteoclasts
Chromosomes, Human, Pair 18
Bone and Bones
Mutation
Conditioned Culture Medium
Interleukin-1
Bone Marrow Cells
Tail
Lower Extremity
Interleukin-6
Histology

Keywords

  • Bone resorption
  • Cytokines
  • Inflammatory bone disease
  • Osteomyelitis

ASJC Scopus subject areas

  • Physiology
  • Hematology

Cite this

Hentunen, T. A., Choi, S. J., Boyce, B. F., Dallas, M. R., Dallas, S. L., Shen-Ong, G. L., & Roodman, G. D. (2000). A murine model of inflammatory bone disease. Bone, 26(2), 183-188. https://doi.org/10.1016/S8756-3282(99)00247-1

A murine model of inflammatory bone disease. / Hentunen, T. A.; Choi, S. J.; Boyce, B. F.; Dallas, M. R.; Dallas, S. L.; Shen-Ong, G. L.; Roodman, G. David.

In: Bone, Vol. 26, No. 2, 02.2000, p. 183-188.

Research output: Contribution to journalArticle

Hentunen, TA, Choi, SJ, Boyce, BF, Dallas, MR, Dallas, SL, Shen-Ong, GL & Roodman, GD 2000, 'A murine model of inflammatory bone disease', Bone, vol. 26, no. 2, pp. 183-188. https://doi.org/10.1016/S8756-3282(99)00247-1
Hentunen TA, Choi SJ, Boyce BF, Dallas MR, Dallas SL, Shen-Ong GL et al. A murine model of inflammatory bone disease. Bone. 2000 Feb;26(2):183-188. https://doi.org/10.1016/S8756-3282(99)00247-1
Hentunen, T. A. ; Choi, S. J. ; Boyce, B. F. ; Dallas, M. R. ; Dallas, S. L. ; Shen-Ong, G. L. ; Roodman, G. David. / A murine model of inflammatory bone disease. In: Bone. 2000 ; Vol. 26, No. 2. pp. 183-188.
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