A National Study on the Effects of Concussion in Collegiate Athletes and US Military Service Academy Members: The NCAA–DoD Concussion Assessment, Research and Education (CARE) Consortium Structure and Methods

Care Consortium Investigators

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Background: The natural history of mild traumatic brain injury (TBI) or concussion remains poorly defined and no objective biomarker of physiological recovery exists for clinical use. The National Collegiate Athletic Association (NCAA) and the US Department of Defense (DoD) established the Concussion Assessment, Research and Education (CARE) Consortium to study the natural history of clinical and neurobiological recovery after concussion in the service of improved injury prevention, safety and medical care for student-athletes and military personnel. Objectives: The objectives of this paper were to (i) describe the background and driving rationale for the CARE Consortium; (ii) outline the infrastructure of the Consortium policies, procedures, and governance; (iii) describe the longitudinal 6-month clinical and neurobiological study methodology; and (iv) characterize special considerations in the design and implementation of a multicenter trial. Methods: Beginning Fall 2014, CARE Consortium institutions have recruited and enrolled 23,533 student-athletes and military service academy students (approximately 90% of eligible student-athletes and cadets; 64.6% male, 35.4% female). A total of 1174 concussions have been diagnosed in participating subjects, with both concussion and baseline cases deposited in the Federal Interagency Traumatic Brain Injury Research (FITBIR) database. Conclusions: Challenges have included coordinating regulatory issues across civilian and military institutions, operationalizing study procedures, neuroimaging protocol harmonization across sites and platforms, construction and maintenance of a relational database, and data quality and integrity monitoring. The NCAA–DoD CARE Consortium represents a comprehensive investigation of concussion in student-athletes and military service academy students. The richly characterized study sample and multidimensional approach provide an opportunity to advance the field of concussion science, not only among student athletes but in all populations at risk for mild TBI.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalSports Medicine
DOIs
StateAccepted/In press - Mar 9 2017

Fingerprint

Athletes
Brain Concussion
Students
Education
Research
United States Department of Defense
Databases
Military Personnel
Natural History
Medical Students
Neuroimaging
Multicenter Studies
Sports
Biomarkers
Maintenance
Safety
Wounds and Injuries

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

@article{859f5db7b69749cab13ec47663974d68,
title = "A National Study on the Effects of Concussion in Collegiate Athletes and US Military Service Academy Members: The NCAA–DoD Concussion Assessment, Research and Education (CARE) Consortium Structure and Methods",
abstract = "Background: The natural history of mild traumatic brain injury (TBI) or concussion remains poorly defined and no objective biomarker of physiological recovery exists for clinical use. The National Collegiate Athletic Association (NCAA) and the US Department of Defense (DoD) established the Concussion Assessment, Research and Education (CARE) Consortium to study the natural history of clinical and neurobiological recovery after concussion in the service of improved injury prevention, safety and medical care for student-athletes and military personnel. Objectives: The objectives of this paper were to (i) describe the background and driving rationale for the CARE Consortium; (ii) outline the infrastructure of the Consortium policies, procedures, and governance; (iii) describe the longitudinal 6-month clinical and neurobiological study methodology; and (iv) characterize special considerations in the design and implementation of a multicenter trial. Methods: Beginning Fall 2014, CARE Consortium institutions have recruited and enrolled 23,533 student-athletes and military service academy students (approximately 90{\%} of eligible student-athletes and cadets; 64.6{\%} male, 35.4{\%} female). A total of 1174 concussions have been diagnosed in participating subjects, with both concussion and baseline cases deposited in the Federal Interagency Traumatic Brain Injury Research (FITBIR) database. Conclusions: Challenges have included coordinating regulatory issues across civilian and military institutions, operationalizing study procedures, neuroimaging protocol harmonization across sites and platforms, construction and maintenance of a relational database, and data quality and integrity monitoring. The NCAA–DoD CARE Consortium represents a comprehensive investigation of concussion in student-athletes and military service academy students. The richly characterized study sample and multidimensional approach provide an opportunity to advance the field of concussion science, not only among student athletes but in all populations at risk for mild TBI.",
author = "{Care Consortium Investigators} and Broglio, {Steven P.} and Michael McCrea and Thomas McAllister and Jaroslaw Harezlak and Barry Katz and Dallas Hack and Brian Hainline and April Hoy and Kelly, {Louise A.} and Hazzard, {Joseph B.} and Nicholas Port and Margot Putukian and Langford, {T. Dianne} and Ryan Tierney and Campbell, {Darren E.} and Gerald McGinty and Patrick O’Donnell and Benjamin, {Holly J.} and Thomas Buckley and Kaminski, {Thomas W.} and Clugston, {James R.} and Schmidt, {Julianne D.} and Feigenbaum, {Luis A.} and Eckner, {James T.} and Kevin Guskiewicz and Mihalik, {Jason P.} and Miles, {Jessica Dysart} and Master, {Christina L.} and Micky Collins and Kontos, {Anthony P.} and Bazarian, {Jeffrey J.} and Chrisman, {Sara P.D.} and Bullers, {Christopher Todd} and Miles, {Christopher M.} and Dykhuizen, {Brian H.}",
year = "2017",
month = "3",
day = "9",
doi = "10.1007/s40279-017-0707-1",
language = "English (US)",
pages = "1--15",
journal = "Sports Medicine",
issn = "0112-1642",
publisher = "Springer International Publishing AG",

}

TY - JOUR

T1 - A National Study on the Effects of Concussion in Collegiate Athletes and US Military Service Academy Members

T2 - The NCAA–DoD Concussion Assessment, Research and Education (CARE) Consortium Structure and Methods

AU - Care Consortium Investigators

AU - Broglio, Steven P.

AU - McCrea, Michael

AU - McAllister, Thomas

AU - Harezlak, Jaroslaw

AU - Katz, Barry

AU - Hack, Dallas

AU - Hainline, Brian

AU - Hoy, April

AU - Kelly, Louise A.

AU - Hazzard, Joseph B.

AU - Port, Nicholas

AU - Putukian, Margot

AU - Langford, T. Dianne

AU - Tierney, Ryan

AU - Campbell, Darren E.

AU - McGinty, Gerald

AU - O’Donnell, Patrick

AU - Benjamin, Holly J.

AU - Buckley, Thomas

AU - Kaminski, Thomas W.

AU - Clugston, James R.

AU - Schmidt, Julianne D.

AU - Feigenbaum, Luis A.

AU - Eckner, James T.

AU - Guskiewicz, Kevin

AU - Mihalik, Jason P.

AU - Miles, Jessica Dysart

AU - Master, Christina L.

AU - Collins, Micky

AU - Kontos, Anthony P.

AU - Bazarian, Jeffrey J.

AU - Chrisman, Sara P.D.

AU - Bullers, Christopher Todd

AU - Miles, Christopher M.

AU - Dykhuizen, Brian H.

PY - 2017/3/9

Y1 - 2017/3/9

N2 - Background: The natural history of mild traumatic brain injury (TBI) or concussion remains poorly defined and no objective biomarker of physiological recovery exists for clinical use. The National Collegiate Athletic Association (NCAA) and the US Department of Defense (DoD) established the Concussion Assessment, Research and Education (CARE) Consortium to study the natural history of clinical and neurobiological recovery after concussion in the service of improved injury prevention, safety and medical care for student-athletes and military personnel. Objectives: The objectives of this paper were to (i) describe the background and driving rationale for the CARE Consortium; (ii) outline the infrastructure of the Consortium policies, procedures, and governance; (iii) describe the longitudinal 6-month clinical and neurobiological study methodology; and (iv) characterize special considerations in the design and implementation of a multicenter trial. Methods: Beginning Fall 2014, CARE Consortium institutions have recruited and enrolled 23,533 student-athletes and military service academy students (approximately 90% of eligible student-athletes and cadets; 64.6% male, 35.4% female). A total of 1174 concussions have been diagnosed in participating subjects, with both concussion and baseline cases deposited in the Federal Interagency Traumatic Brain Injury Research (FITBIR) database. Conclusions: Challenges have included coordinating regulatory issues across civilian and military institutions, operationalizing study procedures, neuroimaging protocol harmonization across sites and platforms, construction and maintenance of a relational database, and data quality and integrity monitoring. The NCAA–DoD CARE Consortium represents a comprehensive investigation of concussion in student-athletes and military service academy students. The richly characterized study sample and multidimensional approach provide an opportunity to advance the field of concussion science, not only among student athletes but in all populations at risk for mild TBI.

AB - Background: The natural history of mild traumatic brain injury (TBI) or concussion remains poorly defined and no objective biomarker of physiological recovery exists for clinical use. The National Collegiate Athletic Association (NCAA) and the US Department of Defense (DoD) established the Concussion Assessment, Research and Education (CARE) Consortium to study the natural history of clinical and neurobiological recovery after concussion in the service of improved injury prevention, safety and medical care for student-athletes and military personnel. Objectives: The objectives of this paper were to (i) describe the background and driving rationale for the CARE Consortium; (ii) outline the infrastructure of the Consortium policies, procedures, and governance; (iii) describe the longitudinal 6-month clinical and neurobiological study methodology; and (iv) characterize special considerations in the design and implementation of a multicenter trial. Methods: Beginning Fall 2014, CARE Consortium institutions have recruited and enrolled 23,533 student-athletes and military service academy students (approximately 90% of eligible student-athletes and cadets; 64.6% male, 35.4% female). A total of 1174 concussions have been diagnosed in participating subjects, with both concussion and baseline cases deposited in the Federal Interagency Traumatic Brain Injury Research (FITBIR) database. Conclusions: Challenges have included coordinating regulatory issues across civilian and military institutions, operationalizing study procedures, neuroimaging protocol harmonization across sites and platforms, construction and maintenance of a relational database, and data quality and integrity monitoring. The NCAA–DoD CARE Consortium represents a comprehensive investigation of concussion in student-athletes and military service academy students. The richly characterized study sample and multidimensional approach provide an opportunity to advance the field of concussion science, not only among student athletes but in all populations at risk for mild TBI.

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U2 - 10.1007/s40279-017-0707-1

DO - 10.1007/s40279-017-0707-1

M3 - Article

C2 - 28281095

AN - SCOPUS:85014709392

SP - 1

EP - 15

JO - Sports Medicine

JF - Sports Medicine

SN - 0112-1642

ER -