A neuroprotective peptide antagonizes fetal alcohol exposure-compromised brain growth

Feng Zhou, Youssef Sari, Teresa A. Powrozek, Catherine Y. Spong

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We evaluated a 9-amino-acid peptide, SALLRSIPA (SAL), an agonist of activity-dependent neurotrophic factor (ADNF), for its protective properties against fetal alcohol-related brain growth retardation, using an established liquid diet model of alcohol-related neurodevelopmental disorder (ARND) in C57BL/6 mice. Alcohol exposure during neurulation reduced body weight, head size, and specifically brain weight and volume. Major gross brain deficits include underdevelopment of brain areas, cortical thinning, ventricle enlargement, and restricted midline neural tissue growth leading to openings at the roof/floor plate. SALLRSIPA (SAL) treatment increased fetal body weight and restored brain weight, brain volume, and regional brain size. Furthermore, SAL restored cortical thickness, reduced the size and frequency of neural tube openings, and attenuated ventricular enlargement. The ability of SAL to antagonize alcohol-retarded brain growth and development of forebrain and midline neural tube at midgestation suggests its potential use as an antagonist against fetal alcohol-rendered microencephaly early in development.

Original languageEnglish
Pages (from-to)189-199
Number of pages11
JournalJournal of Molecular Neuroscience
Volume24
Issue number2
DOIs
StatePublished - Sep 2004

Fingerprint

Brain
Alcohols
Peptides
Growth
Neural Tube
Neurulation
Fetal Alcohol Spectrum Disorders
Weights and Measures
Fetal Weight
Nutrition
Prosencephalon
Inbred C57BL Mouse
Growth and Development
Roofs
Head
Body Weight
Tissue
Diet
Amino Acids
SALLRSIPA

Keywords

  • Brain development
  • Fetal alcohol effect
  • Fetal alcohol syndrome
  • Microencephaly
  • Neurotrophic factor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry
  • Genetics

Cite this

A neuroprotective peptide antagonizes fetal alcohol exposure-compromised brain growth. / Zhou, Feng; Sari, Youssef; Powrozek, Teresa A.; Spong, Catherine Y.

In: Journal of Molecular Neuroscience, Vol. 24, No. 2, 09.2004, p. 189-199.

Research output: Contribution to journalArticle

Zhou, Feng ; Sari, Youssef ; Powrozek, Teresa A. ; Spong, Catherine Y. / A neuroprotective peptide antagonizes fetal alcohol exposure-compromised brain growth. In: Journal of Molecular Neuroscience. 2004 ; Vol. 24, No. 2. pp. 189-199.
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