A neuropsychological analysis of schizophrenic thought disorder

Paul G. Nestor, Martha E. Shenton, Cindy Wible, Hiroto Hokama, Brian F. O'Donnell, Susan Law, Robert W. McCarley

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

We examined the relationship of schizophrenic thought disorder, as measured by the Thought Disorder Index (TDI), with (1) neuropsychological measures of verbal memory, abstraction, executive function, visual memory, and working memory; and (2) quantitative MRI measures of prefrontal and basal ganglia structures. TDI scores correlated strongly with rests of verbal memory, abstraction and executive functions, modestly with tests of working memory, but did not correlate with scores on tests of visual memory. Neither TDI scores nor their neuropsychological correlates were associated with frontal or basal ganglia magnetic resonance imaging (MRI) measures, with the exception of the measures of working memory that demonstrated a modest relationship with frontal and basal ganglia structures. These findings suggest that schizophrenic thought disorder may be strongly related to neuropsychological impairments in verbal memory, abstraction and executive functions, and modestly related to problems with working memory in this sample of patients.

Original languageEnglish (US)
Pages (from-to)217-225
Number of pages9
JournalSchizophrenia Research
Volume29
Issue number3
DOIs
StatePublished - Feb 9 1998
Externally publishedYes

Keywords

  • Magnetic resonance imaging
  • Neuropsychology
  • Schizophrenia
  • Semantic memory
  • Thought disorder
  • Working memory

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Nestor, P. G., Shenton, M. E., Wible, C., Hokama, H., O'Donnell, B. F., Law, S., & McCarley, R. W. (1998). A neuropsychological analysis of schizophrenic thought disorder. Schizophrenia Research, 29(3), 217-225. https://doi.org/10.1016/S0920-9964(97)00101-1