A new connection between the spindle checkpoint, asymmetric cell division and cytokine signaling

Charlie Mantel, Hal E. Broxmeyer

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

It is apparent from recent experimental evidence that a more detailed understanding of cancer stem cells is an important, yet poorly explored, aspect of tumor biology. It is believed that greater understanding of cancer stem cells could enhance treatment strategies for this disease. Understanding molecular mechanisms of self-renewal and differentiation of normal stem cells, such as hematopoietic stem cells, is a vital part of this emerging field. We have recently reported a new link between an important cell cycle timer/regulator, MAD2, and the cytokine, stem cell factor, and it's receptor. Here we comment on potential implications of these new findings for understanding stem cell self-renewal and present new data supporting our interpretations.

Original languageEnglish (US)
Pages (from-to)144-146
Number of pages3
JournalCell Cycle
Volume6
Issue number2
DOIs
StatePublished - Jan 15 2007

Keywords

  • Cell cycle
  • MAD2
  • Self-renewal
  • Spindle checkpoint
  • Spindle positioning
  • Stem cell
  • Stem cell factor

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry
  • Molecular Biology

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