A new overgrowth syndrome with accelerated skeletal maturation, unusual facies, and camptodactyly

David D. Weaver, C. Benjamin Graham, I. T. Thomas, David W. Smith

Research output: Contribution to journalArticle

103 Scopus citations

Abstract

Two strikingly similar unrelated male children have the following pattern of anomalies: accelerated growth and osseous maturation, unusual craniofacial appearance, hoarse and low-pitched cry, and hypertonia with camptodactyly. The craniofacial abnormalities include large ears, broad forehead with hypertelorism, and long philtrum in relation to the relatively small mouth and mandible. The excessive growth is of prenatal onset and has continued at two to three times the normal rate with dysharmonic acceleration of skeletal maturation.

Original languageEnglish (US)
Pages (from-to)547-552
Number of pages6
JournalThe Journal of pediatrics
Volume84
Issue number4
DOIs
StatePublished - Apr 1974
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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