Two strikingly similar unrelated male children have the following pattern of anomalies: accelerated growth and osseous maturation, unusual craniofacial appearance, hoarse and low-pitched cry, and hypertonia with camptodactyly. The craniofacial abnormalities include large ears, broad forehead with hypertelorism, and long philtrum in relation to the relatively small mouth and mandible. The excessive growth is of prenatal onset and has continued at two to three times the normal rate with dysharmonic acceleration of skeletal maturation.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health