A new target for athritis therapy: Advance in the study of aggrecanase

Jing Ya Li, Qi Zhuang Ye

Research output: Contribution to journalArticle


Aggrecan degradation is an important factor in the erosion of articular cartilage in arthritis. Aggrecanase is a newly cloned enzyme which degrades the core protein of aggrecan between the GLu373 and Ala374, a site different from the matrix metalloproteinases cleavage site, Asn341 ∼ Phe342. The discovery of aggrecanase and searching for its inhibitors will accelerate the development of therapeutic agents for arthritis.

Original languageEnglish (US)
Pages (from-to)656-657
Number of pages2
JournalProgress in Biochemistry and Biophysics
Issue number5
StatePublished - Dec 1 2001



  • Aggrecanase
  • Aggrecanse
  • Arthritis
  • Enzyme inhibitor
  • Matrix metalloproteinases

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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