A new target for athritis therapy

Advance in the study of aggrecanase

Jing Ya Li, Qizhuang Ye

Research output: Contribution to journalArticle

Abstract

Aggrecan degradation is an important factor in the erosion of articular cartilage in arthritis. Aggrecanase is a newly cloned enzyme which degrades the core protein of aggrecan between the GLu373 and Ala374, a site different from the matrix metalloproteinases cleavage site, Asn341 ∼ Phe342. The discovery of aggrecanase and searching for its inhibitors will accelerate the development of therapeutic agents for arthritis.

Original languageEnglish (US)
Pages (from-to)656-657
Number of pages2
JournalProgress in Biochemistry and Biophysics
Volume28
Issue number5
StatePublished - 2001
Externally publishedYes

Fingerprint

Aggrecans
Arthritis
Cartilage
Articular Cartilage
Matrix Metalloproteinases
Erosion
Degradation
Enzymes
Therapeutics
Proteins
aggrecanase

Keywords

  • Aggrecanase
  • Aggrecanse
  • Arthritis
  • Enzyme inhibitor
  • Matrix metalloproteinases

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Cite this

A new target for athritis therapy : Advance in the study of aggrecanase. / Li, Jing Ya; Ye, Qizhuang.

In: Progress in Biochemistry and Biophysics, Vol. 28, No. 5, 2001, p. 656-657.

Research output: Contribution to journalArticle

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