Aggrecan degradation is an important factor in the erosion of articular cartilage in arthritis. Aggrecanase is a newly cloned enzyme which degrades the core protein of aggrecan between the GLu373 and Ala374, a site different from the matrix metalloproteinases cleavage site, Asn341 ∼ Phe342. The discovery of aggrecanase and searching for its inhibitors will accelerate the development of therapeutic agents for arthritis.
|Original language||English (US)|
|Number of pages||2|
|Journal||Progress in Biochemistry and Biophysics|
|State||Published - Dec 1 2001|
- Enzyme inhibitor
- Matrix metalloproteinases
ASJC Scopus subject areas