A new tiazofurin pronucleotide: Synthesis and biological evaluation of cyclosaligenyl-tiazofurin monophosphate

L. Cappellacci, G. Barboni, P. Franchetti, C. Martini, H. N. Jayaram, M. Grifantini

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Synthesis and biological activities of cyclosaligenyl-tiazofurin monophosphate (CycloSal-TRMP), a new tiazofurin pronucleotide, are reported. CycloSal-TRMP proved to be active in vitro against human myelogenous leukemia K562 cell line and as A1 adenosine receptor agonist.

Original languageEnglish
Pages (from-to)869-872
Number of pages4
JournalNucleosides, Nucleotides and Nucleic Acids
Volume22
Issue number5-8
DOIs
StatePublished - 2003

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tiazofurin
Adenosine A1 Receptor Agonists
Myeloid Leukemia
K562 Cells
Bioactivity
Cells
Cell Line
tiazofurin monophosphate

Keywords

  • Anticancer
  • CycloSal-pronucleotide
  • IMPDH inhibitor
  • Tiazofurin

ASJC Scopus subject areas

  • Genetics
  • Biochemistry

Cite this

A new tiazofurin pronucleotide : Synthesis and biological evaluation of cyclosaligenyl-tiazofurin monophosphate. / Cappellacci, L.; Barboni, G.; Franchetti, P.; Martini, C.; Jayaram, H. N.; Grifantini, M.

In: Nucleosides, Nucleotides and Nucleic Acids, Vol. 22, No. 5-8, 2003, p. 869-872.

Research output: Contribution to journalArticle

Cappellacci, L, Barboni, G, Franchetti, P, Martini, C, Jayaram, HN & Grifantini, M 2003, 'A new tiazofurin pronucleotide: Synthesis and biological evaluation of cyclosaligenyl-tiazofurin monophosphate', Nucleosides, Nucleotides and Nucleic Acids, vol. 22, no. 5-8, pp. 869-872. https://doi.org/10.1081/NCN-120022674
Cappellacci, L. ; Barboni, G. ; Franchetti, P. ; Martini, C. ; Jayaram, H. N. ; Grifantini, M. / A new tiazofurin pronucleotide : Synthesis and biological evaluation of cyclosaligenyl-tiazofurin monophosphate. In: Nucleosides, Nucleotides and Nucleic Acids. 2003 ; Vol. 22, No. 5-8. pp. 869-872.
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