A new wrinkle on topical vitamin E and photo-inflammation: Mechanistic studies of a hydrophilic γ-tocopherol derivative compared with α-tocopherol

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Abstract

The antioxidant function of vitamin E is thought to mediate its photo-protective effects. Cyclooxygenase-2 (COX-2) is an important mediator of early photo-inflammation. Thus, the ability of γ-tocopherol to inhibit COX-2 activity independently of its antioxidant function raises important questions regarding potential roles that this form of vitamin E plays in photo-protection and skin cancer chemoprevention.

Original languageEnglish
Pages (from-to)1447-1449
Number of pages3
JournalJournal of Investigative Dermatology
Volume126
Issue number7
DOIs
StatePublished - Jul 2006

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Tocopherols
Cyclooxygenase 2
Vitamin E
Antioxidants
Inflammation
Derivatives
Chemoprevention
Skin Neoplasms
Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

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title = "A new wrinkle on topical vitamin E and photo-inflammation: Mechanistic studies of a hydrophilic γ-tocopherol derivative compared with α-tocopherol",
abstract = "The antioxidant function of vitamin E is thought to mediate its photo-protective effects. Cyclooxygenase-2 (COX-2) is an important mediator of early photo-inflammation. Thus, the ability of γ-tocopherol to inhibit COX-2 activity independently of its antioxidant function raises important questions regarding potential roles that this form of vitamin E plays in photo-protection and skin cancer chemoprevention.",
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