A new wrinkle on topical vitamin E and photo-inflammation: Mechanistic studies of a hydrophilic γ-tocopherol derivative compared with α-tocopherol

Research output: Contribution to journalComment/debate

11 Scopus citations

Abstract

The antioxidant function of vitamin E is thought to mediate its photo-protective effects. Cyclooxygenase-2 (COX-2) is an important mediator of early photo-inflammation. Thus, the ability of γ-tocopherol to inhibit COX-2 activity independently of its antioxidant function raises important questions regarding potential roles that this form of vitamin E plays in photo-protection and skin cancer chemoprevention.

Original languageEnglish (US)
Pages (from-to)1447-1449
Number of pages3
JournalJournal of Investigative Dermatology
Volume126
Issue number7
DOIs
StatePublished - Jul 2006

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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