A non-canonical role for β-secretase in the retina

Qingwen Qian, Sayak K. Mitter, S. Louise Pay, Xiaoping Qi, Catherine Bowes Rickman, Maria B. Grant, Michael E. Boulton

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

It has long been established that β-Secretase (BACE) plays a critical role in the formation of amyloid plaques in Alzheimer’s Disease patients, but it is only recently that the importance of β-secretases in retinal pathophysiology has been recognized. BACE expression is elevated in response to stress, and downregulation results in lysosomal abnormalities and mitochondrial changes. Inhibition of BACE can lead to reduced retinal function, retinal thinning, lipofuscin accumulation and vascular dysfunction in mice. Furthermore, BACE inhibition accelerates choroidal neovascularization (CNV) in mice. We propose that BACE plays an important role in retinal homeostasis and that BACE upregulation in response to stress is a protective measure.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages333-339
Number of pages7
Volume854
DOIs
StatePublished - Oct 1 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume854
ISSN (Print)00652598
ISSN (Electronic)22148019

Keywords

  • Agerelated macular degeneration
  • Angiogenesis
  • Choroidal neovascularisation
  • Lysosomes
  • Mitochondria
  • Retinal degeneration
  • Retinal pigment epithelium
  • β-secretase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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