A noninvasive protocol for anterior temporal lobectomy

M. R. Sperling, M. J. O'Connor, Andrew Saykin, C. A. Phillips, M. J. Morrell, P. A. Bridgman, J. A. French, N. Gonatas

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

We report the results of a protocol for choosing candidates for temporal lobectomy using a standard battery of objective tests without intracranial electrodes. We assigned each test a level of importance, and an algorithm was used to determine whether temporal lobectomy could be performed. Fifty-one patients (total pool, 103 patients) met protocol requirements and had an anterior temporal lobectomy with a mean follow-up of 39.4 months (range, 21 to 64 months), most remaining on anticonvulsant therapy. Eighty percent are seizure free, 12% have 80% reduction in seizure frequency. One-third of patients who failed protocol criteria did not have temporal lobe seizures when studied with intracranial electrodes. We analyzed and modified the algorithm after comparing these patients with others who were poor candidates for temporal lobectomy. We conclude that this protocol is effective and recommend using such an objective algorithm.

Original languageEnglish (US)
Pages (from-to)416-422
Number of pages7
JournalNeurology
Volume42
Issue number2
StatePublished - 1992
Externally publishedYes

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Anterior Temporal Lobectomy
Seizures
Electrodes
Temporal Lobe
Anticonvulsants

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Sperling, M. R., O'Connor, M. J., Saykin, A., Phillips, C. A., Morrell, M. J., Bridgman, P. A., ... Gonatas, N. (1992). A noninvasive protocol for anterior temporal lobectomy. Neurology, 42(2), 416-422.

A noninvasive protocol for anterior temporal lobectomy. / Sperling, M. R.; O'Connor, M. J.; Saykin, Andrew; Phillips, C. A.; Morrell, M. J.; Bridgman, P. A.; French, J. A.; Gonatas, N.

In: Neurology, Vol. 42, No. 2, 1992, p. 416-422.

Research output: Contribution to journalArticle

Sperling, MR, O'Connor, MJ, Saykin, A, Phillips, CA, Morrell, MJ, Bridgman, PA, French, JA & Gonatas, N 1992, 'A noninvasive protocol for anterior temporal lobectomy', Neurology, vol. 42, no. 2, pp. 416-422.
Sperling MR, O'Connor MJ, Saykin A, Phillips CA, Morrell MJ, Bridgman PA et al. A noninvasive protocol for anterior temporal lobectomy. Neurology. 1992;42(2):416-422.
Sperling, M. R. ; O'Connor, M. J. ; Saykin, Andrew ; Phillips, C. A. ; Morrell, M. J. ; Bridgman, P. A. ; French, J. A. ; Gonatas, N. / A noninvasive protocol for anterior temporal lobectomy. In: Neurology. 1992 ; Vol. 42, No. 2. pp. 416-422.
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