A noninvasive protocol for anterior temporal lobectomy

M. R. Sperling, M. J. O'Connor, A. J. Saykin, C. A. Phillips, M. J. Morrell, P. A. Bridgman, J. A. French, N. Gonatas

Research output: Contribution to journalArticle

127 Scopus citations

Abstract

We report the results of a protocol for choosing candidates for temporal lobectomy using a standard battery of objective tests without intracranial electrodes. We assigned each test a level of importance, and an algorithm was used to determine whether temporal lobectomy could be performed. Fifty-one patients (total pool, 103 patients) met protocol requirements and had an anterior temporal lobectomy with a mean follow-up of 39.4 months (range, 21 to 64 months), most remaining on anticonvulsant therapy. Eighty percent are seizure free, 12% have <3 seizures per year or only nocturnal seizures, and 8% have >80% reduction in seizure frequency. One-third of patients who failed protocol criteria did not have temporal lobe seizures when studied with intracranial electrodes. We analyzed and modified the algorithm after comparing these patients with others who were poor candidates for temporal lobectomy. We conclude that this protocol is effective and recommend using such an objective algorithm.

Original languageEnglish (US)
Pages (from-to)416-422
Number of pages7
JournalNeurology
Volume42
Issue number2
DOIs
StatePublished - Feb 1992
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'A noninvasive protocol for anterior temporal lobectomy'. Together they form a unique fingerprint.

  • Cite this

    Sperling, M. R., O'Connor, M. J., Saykin, A. J., Phillips, C. A., Morrell, M. J., Bridgman, P. A., French, J. A., & Gonatas, N. (1992). A noninvasive protocol for anterior temporal lobectomy. Neurology, 42(2), 416-422. https://doi.org/10.1212/wnl.42.2.416