A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland

Youhang Jiang, Victor C. Yu, Frank Buchholz, Shawn O'Connell, Simon Rhodes, Carlos Candeloro, Yu Rong Xia, Aidons J. Lusis, Michael G. Rosenfeld

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

A screen designed to identify proteins that specifically bind to retinoic acid response elements resulted in the identification of a rat cDNA encoding a novel protein containing six Cys-Cys, His-Cys zinc fingers. This gene is expressed in a restricted fashion exhibiting distinct temporal and spatial patterns in the developing nervous system, primarily brain, spinal cord, sensory ganglia, retina, and nasal epithelia, as well as in the pituitary, and is referred to as neural zinc finger factor 1 (NZF-1). NZF-1 binds specifically to a cis-regulatory element of the β-retinoic acid receptor (RARβ) gene, as well as to other related DNA elements, including two in the upstream enhancer region of the mouse Pit-1 gene. In heterologous cells, NZF- 1 activates transcription from promoters containing specific binding sequences and can synergize with other factors, such as Pit-1, to regulate gene expression. These results suggest that NZF-1 may exert regulatory roles in the developing and mature nervous system and in the pituitary gland. Identification of a second mouse gene highly homologous to NZF-1, encoded by a distinct genomic locus, reveals a dispersed gene family encoding proteins containing Cys-Cys, His-Cys motifs.

Original languageEnglish
Pages (from-to)10723-10730
Number of pages8
JournalJournal of Biological Chemistry
Volume271
Issue number18
DOIs
StatePublished - 1996

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cysteinylcysteine
Zinc Fingers
Neurology
Pituitary Gland
Nervous System
Zinc
Transcription Factors
Genes
Sensory Ganglia
Retinoic Acid Receptors
Proteins
Nasal Mucosa
Response Elements
Transcription
Tretinoin
Gene expression
Retina
Rats
Brain
Spinal Cord

ASJC Scopus subject areas

  • Biochemistry

Cite this

A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland. / Jiang, Youhang; Yu, Victor C.; Buchholz, Frank; O'Connell, Shawn; Rhodes, Simon; Candeloro, Carlos; Xia, Yu Rong; Lusis, Aidons J.; Rosenfeld, Michael G.

In: Journal of Biological Chemistry, Vol. 271, No. 18, 1996, p. 10723-10730.

Research output: Contribution to journalArticle

Jiang, Y, Yu, VC, Buchholz, F, O'Connell, S, Rhodes, S, Candeloro, C, Xia, YR, Lusis, AJ & Rosenfeld, MG 1996, 'A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland', Journal of Biological Chemistry, vol. 271, no. 18, pp. 10723-10730. https://doi.org/10.1074/jbc.271.18.10723
Jiang, Youhang ; Yu, Victor C. ; Buchholz, Frank ; O'Connell, Shawn ; Rhodes, Simon ; Candeloro, Carlos ; Xia, Yu Rong ; Lusis, Aidons J. ; Rosenfeld, Michael G. / A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland. In: Journal of Biological Chemistry. 1996 ; Vol. 271, No. 18. pp. 10723-10730.
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