A novel furanone-modified antibacterial dental glass ionomer cement

Yiming Weng, Leah Howard, Voon Joe Chong, Jun Sun, Richard Gregory, Dong Xie

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A novel furanone derivative and a polyacid constructed from it were synthesized, characterized and formulated into experimental high strength cements. The compressive strength (CS) and Streptococcus mutans viability were used to evaluate the mechanical strength and antibacterial activity of the cements. The effect of human saliva and aging were investigated. The antibacterial activity against Lactobacillus sp. and cytotoxicity to human pulp cells were also evaluated. The results show that all the formulated furanone-containing cements showed antibacterial activity, with an initial reduction in CS. The effect of the furanone derivative loading was significant. Increasing loading enhanced the antibacterial activity but reduced the initial CS of the formed cements. The derivative showed antibacterial activity against both S. mutans and Lactobacillus sp. Human saliva did not affect the antibacterial activity of the cement. The cytotoxicity study with human dental pulp cells shows that the furanone-modified cement was biocompatible. A 30 day aging study indicated that the cements may have long-lasting antibacterial activity. Within the limitations of this study it appears that the experimental cement could be a clinically attractive dental restorative due to its high mechanical strength and antibacterial function.

Original languageEnglish
Pages (from-to)3153-3160
Number of pages8
JournalActa Biomaterialia
Volume8
Issue number8
DOIs
StatePublished - Aug 2012

Fingerprint

Glass Ionomer Cements
Ionomers
Compressive Strength
Tooth
Cements
Glass
Streptococcus mutans
Lactobacillus
Saliva
Compressive strength
Dental Pulp
Cytotoxicity
Derivatives
Pulp
Strength of materials
Aging of materials

Keywords

  • Aging
  • Antibacterial
  • Compressive strength
  • Glass ionomer cement
  • S. mutans viability

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Biotechnology
  • Biochemistry
  • Molecular Biology

Cite this

A novel furanone-modified antibacterial dental glass ionomer cement. / Weng, Yiming; Howard, Leah; Chong, Voon Joe; Sun, Jun; Gregory, Richard; Xie, Dong.

In: Acta Biomaterialia, Vol. 8, No. 8, 08.2012, p. 3153-3160.

Research output: Contribution to journalArticle

Weng, Yiming ; Howard, Leah ; Chong, Voon Joe ; Sun, Jun ; Gregory, Richard ; Xie, Dong. / A novel furanone-modified antibacterial dental glass ionomer cement. In: Acta Biomaterialia. 2012 ; Vol. 8, No. 8. pp. 3153-3160.
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