A novel gibbs maximum a posteriori (GMAP) approach on bayesian nonlinear mixed-effects population pharmacokinetics (PK) models

Seongho Kim, Stephen D. Hall, Lang Li

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

In this paper, various Bayesian Monte Carlo Markov chain (MCMC) methods and the proposed algorithm, the Gibbs maximum a posteriori (GMAP) algorithm, are compared for implementing the nonlinear mixed-effects model in pharmacokinetics (PK) studies. An intravenous two-compartmental PK model is adopted to fit the PK data from the midazolam (MDZ) studies, which recruited twenty-four individuals with nine different time points per subject. The three-stage hierarchical nonlinear mixed model is constructed. Data analysis and model performance comparisons show that GMAP converges the fastest and provides reliable results. At the mean time, data augmentation (DA) methods are used for the Random-walk Metropolis method. Data analysis shows that the speed of the convergence of Random-walk Metropolis can be improved by DA, but all of them are not as fast as GMAP. The performance of GMAP and various MCMC algorithms are compared through Midazolam data analysis and simulation.

Original languageEnglish (US)
Pages (from-to)700-720
Number of pages21
JournalJournal of biopharmaceutical statistics
Volume19
Issue number4
DOIs
StatePublished - Jul 1 2009

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Keywords

  • Bayesian model
  • Gibbs Maximum a Posteriori (GMAP)
  • Monte Carlo Markov Chain (MCMC)
  • Pharmacokinetics (PK)

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Statistics and Probability

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