A novel growth-promoting pathway formed by GDNFoverexpressing Schwann cells promotes propriospinal axonal regeneration, synapse formation, and partial recovery of function after spinal cord injury

Ling Xiao Deng, Ping Deng, Yiwen Ruan, Zao Cheng Xu, Naikui Liu, Xuejun Wen, George M. Smith, Xiao-Ming Xu

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Descending propriospinal neurons (DPSN) are known to establish functional relays for supraspinal signals, and they display a greater growth response after injury than do the long projecting axons. However, their regenerative response is still deficient due to their failure to depart from growth supportive cellular transplants back into the host spinal cord, which contains numerous impediments to axon growth. Here we report the construction of a continuous growth-promoting pathway in adult rats, formed by grafted Schwann cells overexpressing glial cell line-derived neurotrophic factor (GDNF). We demonstrate that such a growth-promoting pathway, extending from the axonal cut ends to the site of innervation in the distal spinal cord, promoted regeneration of DPSNaxons through and beyond the lesion gap of a spinal cord hemisection. Within the distal host spinal cord, regenerated DPSN axons formed synapses with host neurons leading to the restoration of action potentials and partial recovery of function.

Original languageEnglish
Pages (from-to)5655-5667
Number of pages13
JournalJournal of Neuroscience
Volume33
Issue number13
DOIs
StatePublished - Mar 27 2013

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Schwann Cells
Recovery of Function
Spinal Cord Injuries
Synapses
Regeneration
Axons
Growth
Spinal Cord
Neurons
Spinal Cord Regeneration
Glial Cell Line-Derived Neurotrophic Factor
Action Potentials
Transplants
Wounds and Injuries

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A novel growth-promoting pathway formed by GDNFoverexpressing Schwann cells promotes propriospinal axonal regeneration, synapse formation, and partial recovery of function after spinal cord injury. / Deng, Ling Xiao; Deng, Ping; Ruan, Yiwen; Xu, Zao Cheng; Liu, Naikui; Wen, Xuejun; Smith, George M.; Xu, Xiao-Ming.

In: Journal of Neuroscience, Vol. 33, No. 13, 27.03.2013, p. 5655-5667.

Research output: Contribution to journalArticle

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AU - Xu, Zao Cheng

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AU - Wen, Xuejun

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