A novel mast cell growth factor (MCGF-3) produced by marrow-adherent cells that synergizes with interleukin 3 and interleukin 4

H. S. Boswell, D. Y. Mochizuki, G. S. Burgess, S. Gillis, E. B. Walker, D. Anderson, D. E. Williams

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Abstract

A clonal marrow-adherent stromal cell line, +/+-1 LDA11, was derived and found to produce hemopoietic stimulatory activity for an interleukin 3 (IL-3)-dependent mast cell line, NFS/N1. This factor-dependent mast cell line displayed restricted growth factor responsiveness to only IL-3, interleukin 4 (IL-4), and the stromal cell-produced factor. The factor produced by stromal cells was distinguished from IL-3 and IL-4 and was characterized biochemically. This factor appears to be a novel mast cell growth factor (MCGF-3) capable of synergizing with IL-3 and IL-4. It may have broader reactivity in hemopoiesis than simply IL-3-dependent mast cells, and it may prove relevant to stromal cell-mediated hemopoiesis.

Original languageEnglish (US)
Pages (from-to)794-800
Number of pages7
JournalExperimental Hematology
Volume18
Issue number7
StatePublished - Sep 10 1990

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Keywords

  • Mast cells
  • Synergistic factor

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

Cite this

Boswell, H. S., Mochizuki, D. Y., Burgess, G. S., Gillis, S., Walker, E. B., Anderson, D., & Williams, D. E. (1990). A novel mast cell growth factor (MCGF-3) produced by marrow-adherent cells that synergizes with interleukin 3 and interleukin 4. Experimental Hematology, 18(7), 794-800.