A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs

Saurabh Ghosh, Laura J. Bierut, Bernice Porjesz, Howard Edenberg, Danielle Dick, Alison Goate, Victor Hesselbrock, John Nurnberger, Tatiana Foroud, John Kramer, John Rice, Henri Begleiter

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this report,wepresent results of a genome-wide linkage scan using as a phenotype the number of externalizing symptoms associated with alcohol use disorders. Subjects were collected by the Collaborative Studyon the Genetics of Alcoholism project from families in which at least three first degree relatives were affected by alcohol dependence. We use a novel non-parametric regression method based on kernel smoothing for our analysis. We report a statistically significant linkage close to the ADH gene cluster on Chromosome 4. We also obtain evidence for epistatic interaction between a region on Chromosome 1 and one on Chromosome 15. Although alcoholism as a covariate does not have any effect on the linkage scan, it has an effect on the epistatic interaction.

Original languageEnglish
Pages (from-to)1301-1305
Number of pages5
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume147
Issue number7
DOIs
StatePublished - Oct 5 2008

Fingerprint

Chromosomes, Human, Pair 4
Alcoholism
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 1
Multigene Family
Alcohols
Genome
Phenotype

Keywords

  • Externalizing symptoms
  • Linkage
  • Non-parametric regression

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs. / Ghosh, Saurabh; Bierut, Laura J.; Porjesz, Bernice; Edenberg, Howard; Dick, Danielle; Goate, Alison; Hesselbrock, Victor; Nurnberger, John; Foroud, Tatiana; Kramer, John; Rice, John; Begleiter, Henri.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 147, No. 7, 05.10.2008, p. 1301-1305.

Research output: Contribution to journalArticle

Ghosh, Saurabh ; Bierut, Laura J. ; Porjesz, Bernice ; Edenberg, Howard ; Dick, Danielle ; Goate, Alison ; Hesselbrock, Victor ; Nurnberger, John ; Foroud, Tatiana ; Kramer, John ; Rice, John ; Begleiter, Henri. / A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2008 ; Vol. 147, No. 7. pp. 1301-1305.
@article{99dcb1bc2cda42a9bd35016bcfe45662,
title = "A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs",
abstract = "In this report,wepresent results of a genome-wide linkage scan using as a phenotype the number of externalizing symptoms associated with alcohol use disorders. Subjects were collected by the Collaborative Studyon the Genetics of Alcoholism project from families in which at least three first degree relatives were affected by alcohol dependence. We use a novel non-parametric regression method based on kernel smoothing for our analysis. We report a statistically significant linkage close to the ADH gene cluster on Chromosome 4. We also obtain evidence for epistatic interaction between a region on Chromosome 1 and one on Chromosome 15. Although alcoholism as a covariate does not have any effect on the linkage scan, it has an effect on the epistatic interaction.",
keywords = "Externalizing symptoms, Linkage, Non-parametric regression",
author = "Saurabh Ghosh and Bierut, {Laura J.} and Bernice Porjesz and Howard Edenberg and Danielle Dick and Alison Goate and Victor Hesselbrock and John Nurnberger and Tatiana Foroud and John Kramer and John Rice and Henri Begleiter",
year = "2008",
month = "10",
day = "5",
doi = "10.1002/ajmg.b.30735",
language = "English",
volume = "147",
pages = "1301--1305",
journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",
issn = "1552-4841",
publisher = "Wiley-Liss Inc.",
number = "7",

}

TY - JOUR

T1 - A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs

AU - Ghosh, Saurabh

AU - Bierut, Laura J.

AU - Porjesz, Bernice

AU - Edenberg, Howard

AU - Dick, Danielle

AU - Goate, Alison

AU - Hesselbrock, Victor

AU - Nurnberger, John

AU - Foroud, Tatiana

AU - Kramer, John

AU - Rice, John

AU - Begleiter, Henri

PY - 2008/10/5

Y1 - 2008/10/5

N2 - In this report,wepresent results of a genome-wide linkage scan using as a phenotype the number of externalizing symptoms associated with alcohol use disorders. Subjects were collected by the Collaborative Studyon the Genetics of Alcoholism project from families in which at least three first degree relatives were affected by alcohol dependence. We use a novel non-parametric regression method based on kernel smoothing for our analysis. We report a statistically significant linkage close to the ADH gene cluster on Chromosome 4. We also obtain evidence for epistatic interaction between a region on Chromosome 1 and one on Chromosome 15. Although alcoholism as a covariate does not have any effect on the linkage scan, it has an effect on the epistatic interaction.

AB - In this report,wepresent results of a genome-wide linkage scan using as a phenotype the number of externalizing symptoms associated with alcohol use disorders. Subjects were collected by the Collaborative Studyon the Genetics of Alcoholism project from families in which at least three first degree relatives were affected by alcohol dependence. We use a novel non-parametric regression method based on kernel smoothing for our analysis. We report a statistically significant linkage close to the ADH gene cluster on Chromosome 4. We also obtain evidence for epistatic interaction between a region on Chromosome 1 and one on Chromosome 15. Although alcoholism as a covariate does not have any effect on the linkage scan, it has an effect on the epistatic interaction.

KW - Externalizing symptoms

KW - Linkage

KW - Non-parametric regression

UR - http://www.scopus.com/inward/record.url?scp=55349106218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55349106218&partnerID=8YFLogxK

U2 - 10.1002/ajmg.b.30735

DO - 10.1002/ajmg.b.30735

M3 - Article

C2 - 18454434

AN - SCOPUS:55349106218

VL - 147

SP - 1301

EP - 1305

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 7

ER -