A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs

Saurabh Ghosh, Laura J. Bierut, Bernice Porjesz, Howard J. Edenberg, Danielle Dick, Alison Goate, Victor Hesselbrock, John Nurnberger, Tatiana Foroud, John Kramer, John Rice, Henri Begleiter

Research output: Contribution to journalArticle

4 Scopus citations


In this report,wepresent results of a genome-wide linkage scan using as a phenotype the number of externalizing symptoms associated with alcohol use disorders. Subjects were collected by the Collaborative Studyon the Genetics of Alcoholism project from families in which at least three first degree relatives were affected by alcohol dependence. We use a novel non-parametric regression method based on kernel smoothing for our analysis. We report a statistically significant linkage close to the ADH gene cluster on Chromosome 4. We also obtain evidence for epistatic interaction between a region on Chromosome 1 and one on Chromosome 15. Although alcoholism as a covariate does not have any effect on the linkage scan, it has an effect on the epistatic interaction.

Original languageEnglish (US)
Pages (from-to)1301-1305
Number of pages5
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Issue number7
StatePublished - Oct 5 2008



  • Externalizing symptoms
  • Linkage
  • Non-parametric regression

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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