A novel phantom model for mouse tumor dose assessment under MV beams

Michael S. Gossman, Indra J. Das, Subhash C. Sharma, Jeffrey P. Lopez, Candace M. Howard, Pier Claudio

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In order to determine a mouse's dose accurately and prior to engaging in live mouse radiobiological research, a tissue-equivalent tumor-bearing phantom mouse was constructed and bored to accommodate detectors. Comparisons were made among four different types of radiation detectors, each inserted into the mouse phantom for radiation measurement under a 6 MV linear accelerator beam. Dose detection response from a diode, thermoluminescent dosimeters, and metal-oxide semiconductor field-effect transistors were used and compared to that of a reference pinpoint ionization chamber. A computerized treatment planning system was also directly compared to the chamber. Each detector system demonstrated results similar to the dose computed by the treatment planning system, although some differences were noted. The average disagreement from an accelerator calibrated output dose prescription in the range of 200-400 cGy was -0.4% ± 0.5σ for the diode, -2.4% ± 2.6σ for the TLD, -2.9% ± 5.0σ for the MOSFET, and +1.3% ± 1.4σ for the treatment planning system. This phantom mouse design is unique, simple, reproducible, and therefore recommended as a standard approach to dosimetry for radiobiological mouse studies by means of any of the detectors used in this study. The authors fully advocate for treatment planning modeling when possible prior to linac-based dose delivery.

Original languageEnglish
Pages (from-to)746-753
Number of pages8
JournalHealth Physics
Volume101
Issue number6
DOIs
StatePublished - Dec 2011

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Neoplasms
Radiation
Particle Accelerators
Semiconductors
Oxides
Prescriptions
Metals
Research
Radiation Dosimeters

Keywords

  • accelerators, medical
  • detector, thermoluminescent
  • dose assessment
  • mice

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis
  • Epidemiology

Cite this

Gossman, M. S., Das, I. J., Sharma, S. C., Lopez, J. P., Howard, C. M., & Claudio, P. (2011). A novel phantom model for mouse tumor dose assessment under MV beams. Health Physics, 101(6), 746-753. https://doi.org/10.1097/HP.0b013e31821a4838

A novel phantom model for mouse tumor dose assessment under MV beams. / Gossman, Michael S.; Das, Indra J.; Sharma, Subhash C.; Lopez, Jeffrey P.; Howard, Candace M.; Claudio, Pier.

In: Health Physics, Vol. 101, No. 6, 12.2011, p. 746-753.

Research output: Contribution to journalArticle

Gossman, MS, Das, IJ, Sharma, SC, Lopez, JP, Howard, CM & Claudio, P 2011, 'A novel phantom model for mouse tumor dose assessment under MV beams', Health Physics, vol. 101, no. 6, pp. 746-753. https://doi.org/10.1097/HP.0b013e31821a4838
Gossman MS, Das IJ, Sharma SC, Lopez JP, Howard CM, Claudio P. A novel phantom model for mouse tumor dose assessment under MV beams. Health Physics. 2011 Dec;101(6):746-753. https://doi.org/10.1097/HP.0b013e31821a4838
Gossman, Michael S. ; Das, Indra J. ; Sharma, Subhash C. ; Lopez, Jeffrey P. ; Howard, Candace M. ; Claudio, Pier. / A novel phantom model for mouse tumor dose assessment under MV beams. In: Health Physics. 2011 ; Vol. 101, No. 6. pp. 746-753.
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