A novel role for GM-CSF: Enhancement of pregnancy specific interferon production, ovine trophoblast protein-1

K. Imakawa, S. D. Helmer, Kenneth Nephew, C. S R Meka, R. K. Christenson

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Transient and massive production of ovine trophoblast protein-1 (oTP-1) by preimplantation conceptuses seems to be a critical event required for the establishment of successful pregnancy. We have previously demonstrated that one of several oTP-1 genes is predominantly expressed between days 13 and 20 of pregnancy and that this oTP-1 gene contains an AP-1 site, a transcription enhancer element, in the 5′-flanking region. We have obtained evidence, indicating a linkage between cytokine granulocyte macrophage-colony stimulating factor (GM-CSF) and conceptus production of the trophoblast interferon (IFN), oTP-1. These are: 1) oTP-1 production (bothpolypeptide and mRNA) is enhanced by the addition of GM-CSF in vitro and 2) GM-CSF mRNA is localized in the luminal and glandular epithelium of the uterine endometrium. Based on these observations, we propose that the massive amounts of oTP-1 produced during the period of pregnancy establishment is stimulated at least in part by maternal GM-CSF.

Original languageEnglish (US)
Pages (from-to)1869-1871
Number of pages3
JournalEndocrinology
Volume132
Issue number4
StatePublished - Apr 1993
Externally publishedYes

Fingerprint

Granulocyte-Macrophage Colony-Stimulating Factor
Interferons
Sheep
Pregnancy
Messenger RNA
5' Flanking Region
Transcription Factor AP-1
Trophoblasts
Endometrium
Genes
trophoblastin
Epithelium
Mothers
Cytokines

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Imakawa, K., Helmer, S. D., Nephew, K., Meka, C. S. R., & Christenson, R. K. (1993). A novel role for GM-CSF: Enhancement of pregnancy specific interferon production, ovine trophoblast protein-1. Endocrinology, 132(4), 1869-1871.

A novel role for GM-CSF : Enhancement of pregnancy specific interferon production, ovine trophoblast protein-1. / Imakawa, K.; Helmer, S. D.; Nephew, Kenneth; Meka, C. S R; Christenson, R. K.

In: Endocrinology, Vol. 132, No. 4, 04.1993, p. 1869-1871.

Research output: Contribution to journalArticle

Imakawa, K, Helmer, SD, Nephew, K, Meka, CSR & Christenson, RK 1993, 'A novel role for GM-CSF: Enhancement of pregnancy specific interferon production, ovine trophoblast protein-1', Endocrinology, vol. 132, no. 4, pp. 1869-1871.
Imakawa, K. ; Helmer, S. D. ; Nephew, Kenneth ; Meka, C. S R ; Christenson, R. K. / A novel role for GM-CSF : Enhancement of pregnancy specific interferon production, ovine trophoblast protein-1. In: Endocrinology. 1993 ; Vol. 132, No. 4. pp. 1869-1871.
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