A novel structure-aware sparse learning algorithm for brain imaging genetics

Lei Du, Jingwen Yan, Sungeun Kim, Shannon L. Risacher, Heng Huang, Mark Inlow, Jason H. Moore, Andrew J. Saykin, Li Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

24 Scopus citations

Abstract

Brain imaging genetics is an emergent research field where the association between genetic variations such as single nucleotide polymorphisms (SNPs) and neuroimaging quantitative traits (QTs) is evaluated. Sparse canonical correlation analysis (SCCA) is a bi-multivariate analysis method that has the potential to reveal complex multi-SNP-multi-QT associations. Most existing SCCA algorithms are designed using the soft threshold strategy, which assumes that the features in the data are independent from each other. This independence assumption usually does not hold in imaging genetic data, and thus inevitably limits the capability of yielding optimal solutions. We propose a novel structure-aware SCCA (denoted as S2CCA) algorithm to not only eliminate the independence assumption for the input data, but also incorporate group-like structure in the model. Empirical comparison with a widely used SCCA implementation, on both simulated and real imaging genetic data, demonstrated that S2CCA could yield improved prediction performance and biologically meaningful findings.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention, MICCAI 2014 - 17th International Conference, Proceedings
PublisherSpringer Verlag
Pages329-336
Number of pages8
EditionPART 3
ISBN (Print)9783319104423
DOIs
StatePublished - 2014
Externally publishedYes
Event17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014 - Boston, MA, United States
Duration: Sep 14 2014Sep 18 2014

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 3
Volume8675 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014
CountryUnited States
CityBoston, MA
Period9/14/149/18/14

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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