A novel three-dimensional scaffold for regenerative endodontics: Materials and biological characterizations

Marco Bottino, Ghaeth H. Yassen, Jeffrey A. Platt, Nawaf Labban, L. Jack Windsor, Kenneth J. Spolnik, Ana H A Bressiani

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

An electrospun nanocomposite fibrous material holds promise as a scaffold, as well as a drug-delivery device to aid in root maturogenesis and the regeneration of the pulp-dentine complex. A novel three-dimensional (3D) nanocomposite scaffold composed of polydioxanone (PDS II®) and halloysite nanotubes (HNTs) was designed and fabricated by electrospinning. Morphology, structure, mechanical properties and cell compatibility studies were carried out to evaluate the effects of HNTs incorporation (0.5-10wt% relative to PDS w/w). Overall, a 3D porous network was seen in the different fabricated electrospun scaffolds, regardless of the HNT content. The incorporation of HNTs at 10wt% led to a significant (p

Original languageEnglish (US)
Pages (from-to)E116-E123
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume9
Issue number11
DOIs
StatePublished - Nov 1 2015

Keywords

  • Electrospinning
  • Halloysite
  • Immature tooth
  • Pulp regeneration
  • Scaffold

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Biomaterials

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