A novel three-dimensional scaffold for regenerative endodontics: Materials and biological characterizations

Marco C. Bottino, Ghaeth H. Yassen, Jeffrey Platt, Nawaf Labban, L. Windsor, Kenneth Spolnik, Ana H A Bressiani

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

An electrospun nanocomposite fibrous material holds promise as a scaffold, as well as a drug-delivery device to aid in root maturogenesis and the regeneration of the pulp-dentine complex. A novel three-dimensional (3D) nanocomposite scaffold composed of polydioxanone (PDS II®) and halloysite nanotubes (HNTs) was designed and fabricated by electrospinning. Morphology, structure, mechanical properties and cell compatibility studies were carried out to evaluate the effects of HNTs incorporation (0.5-10wt% relative to PDS w/w). Overall, a 3D porous network was seen in the different fabricated electrospun scaffolds, regardless of the HNT content. The incorporation of HNTs at 10wt% led to a significant (p

Original languageEnglish (US)
Pages (from-to)E116-E123
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume9
Issue number11
DOIs
StatePublished - Nov 1 2015

Fingerprint

Nanotubes
Endodontics
Scaffolds
Nanocomposites
Polydioxanone
Electrospinning
Dentin
Drug delivery
Pulp
Regeneration
Equipment and Supplies
Mechanical properties
clay
Pharmaceutical Preparations

Keywords

  • Electrospinning
  • Halloysite
  • Immature tooth
  • Pulp regeneration
  • Scaffold

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Biomaterials

Cite this

A novel three-dimensional scaffold for regenerative endodontics : Materials and biological characterizations. / Bottino, Marco C.; Yassen, Ghaeth H.; Platt, Jeffrey; Labban, Nawaf; Windsor, L.; Spolnik, Kenneth; Bressiani, Ana H A.

In: Journal of Tissue Engineering and Regenerative Medicine, Vol. 9, No. 11, 01.11.2015, p. E116-E123.

Research output: Contribution to journalArticle

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AU - Bressiani, Ana H A

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