A phase I safety study of enzastaurin plus bortezomib in the treatment of relapsed or refractory multiple myeloma

Irene M. Ghobrial, Nikhil C. Munshi, Brianna N. Harris, Peipei Shi, Nichole M. Porter, Robert L. Schlossman, Jacob P. Laubach, Kenneth C. Anderson, Durisala Desaiah, Scott P. Myrand, James E. Wooldridge, Paul G. Richardson, Rafat Abonour

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22 Scopus citations

Abstract

The purpose of this study was to assess the safety and identify the recommended doses of enzastaurin and bortezomib in combination for future Phase II studies in patients with relapsed or refractory multiple myeloma. Three dose levels (DLs) of oral enzastaurin and intravenous bortezomib were used according to a conventional "3 + 3" design. A loading dose of enzastaurin (250 mg twice/day [BID]) on Day 1 was followed by enzastaurin 125 mg BID for 1 week, after which bortezomib was added (Cycle 1, 28 days, 1.0 mg/m2: Days 8, 11, 15, and 18; seven subsequent 21-day cycles, 1.3 mg/m2: Days 1, 4, 8, and 11). Twenty-three patients received treatment; all patients received prior systemic therapy. Most patients received ≥3 regimens; 17 patients were bortezomib-refractory. A median of four treatment cycles (range 1-24) was completed. No dose-limiting toxicities were observed; thus, DL 3 was the recommended Phase II dose. The most common drug-related Grade 3/4 toxicities were thrombocytopenia (n = 6) and anemia (n = 2). No patients died on therapy. One patient (DL 1) achieved a very good partial response; three patients (DLs 2 and 3), a partial response; nine patients, stable disease; and four patients, progressive disease. The recommended Phase II doses in patients with relapsed or refractory multiple myeloma are as follows: enzastaurin loading dose of 375 mg three times/day on Day 1 followed by 250 mg BID, with bortezomib 1.3 mg/m2 on Days 1, 4, 8, and 11 of a 21-day cycle. The combination was well-tolerated and demonstrated some antimyeloma activity.

Original languageEnglish (US)
Pages (from-to)573-578
Number of pages6
JournalAmerican Journal of Hematology
Volume86
Issue number7
DOIs
StatePublished - Jul 1 2011

ASJC Scopus subject areas

  • Hematology

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    Ghobrial, I. M., Munshi, N. C., Harris, B. N., Shi, P., Porter, N. M., Schlossman, R. L., Laubach, J. P., Anderson, K. C., Desaiah, D., Myrand, S. P., Wooldridge, J. E., Richardson, P. G., & Abonour, R. (2011). A phase I safety study of enzastaurin plus bortezomib in the treatment of relapsed or refractory multiple myeloma. American Journal of Hematology, 86(7), 573-578. https://doi.org/10.1002/ajh.22048