A phase II trial of vinorelbine in patients with recurrent or metastatic squamous cell carcinoma of the head and neck

Scott Saxman, Beth Mann, Vikki Canfield, Patrick Loehrer, Everett Vokes

Research output: Contribution to journalArticle

23 Scopus citations


Forty patients with locally advanced, recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) were treated weekly with vinorelbine 30 mg/m2. Thirty-five patients received prior surgery, 20 prior chemotherapy, and 38 prior radiation therapy. Five patients were not evaluable for response and were assumed to be nonresponders. There were three confirmed responders (one complete response, two partial responses) for a response rate of 7.5% (95% confidence interval, 1.6%-20.4%). The median survival time for all patients was 5 months (range, 0.5-50 months), the median progression-free survival time was 2 months (range, 1-49 months). The most common toxicity was myelosuppression, with 60% of patients experiencing grade 3 or higher leukopenia. There was one treatment-related death resulting from sepsis. Vinorelbine has minimal activity in patients with SCCHN that does not exceed that of other currently used agents.

Original languageEnglish (US)
Pages (from-to)398-400
Number of pages3
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Issue number4
StatePublished - Aug 1 1998



  • Head and neck cancer
  • Navelbine
  • Phase II trial
  • Squamous cell carcinoma
  • Vinorelbine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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