A phased-array stimulator system for studying planar and curved cardiac activation wavefronts

Rashida A. Abbas, Shien-Fong Lin, David Mashburn, Junkai Xu, John P. Wikswo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Wavefront propagation in cardiac tissue is affected greatly by the geometry of the wavefront. We describe a computer-controlled stimulator system that creates reproducible wavefronts of a predetermined shape and orientation for the investigation of the effects of wavefront geometry. We conducted demonstration experiments on isolated perfused rabbit hearts, which were stained with the voltage-sensitive dye, di-4-ANEPPS. The wavefronts were imaged using a laser and a charge-coupled device (CCD) camera. The stimulator and imaging systems have been used to characterize the relationship between wavefront velocity and fiber orientation. This approach has potential applications in investigating curvature effects, testing numerical models of cardiac tissue, and creating complex wavefronts using one-, two-, or three-dimensional electrode arrays.

Original languageEnglish
Pages (from-to)222-229
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Volume55
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Wavefronts
Chemical activation
Tissue
Geometry
Fiber reinforced materials
CCD cameras
Imaging systems
Wave propagation
Numerical models
Demonstrations
Dyes
Electrodes
Lasers
Testing
Electric potential
Experiments

Keywords

  • Cardiac conduction velocity
  • Curved activation wavefronts
  • Multisite stimulation
  • Tissue anisotropy

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

A phased-array stimulator system for studying planar and curved cardiac activation wavefronts. / Abbas, Rashida A.; Lin, Shien-Fong; Mashburn, David; Xu, Junkai; Wikswo, John P.

In: IEEE Transactions on Biomedical Engineering, Vol. 55, No. 1, 01.2008, p. 222-229.

Research output: Contribution to journalArticle

Abbas, Rashida A. ; Lin, Shien-Fong ; Mashburn, David ; Xu, Junkai ; Wikswo, John P. / A phased-array stimulator system for studying planar and curved cardiac activation wavefronts. In: IEEE Transactions on Biomedical Engineering. 2008 ; Vol. 55, No. 1. pp. 222-229.
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