A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study

Xueyan Zhao, Xin Geng, Vinodh Srinivasasainagendra, Ninad Chaudhary, Suzanne Judd, Virginia Wadley, Orlando M. Gutiérrez, Henry Wang, Ethan M. Lange, Leslie A. Lange, Daniel Woo, Frederick W. Unverzagt, Monika Safford, Mary Cushman, Nita Limdi, Rakale Quarells, Donna K. Arnett, Marguerite R. Irvin, Degui Zhi

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. Results: In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans. Conclusion: Our cross-racial validation of GWAS findings provide additional evidence for the important roles of these loci in the disease process and may help identify genes especially important for future functional validation.

Original languageEnglish (US)
Article number26
JournalBMC Medical Genomics
Volume12
DOIs
StatePublished - Jan 31 2019

Keywords

  • African Americans
  • Cardiovascular disease
  • Genetics
  • PheWAS

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Zhao, X., Geng, X., Srinivasasainagendra, V., Chaudhary, N., Judd, S., Wadley, V., Gutiérrez, O. M., Wang, H., Lange, E. M., Lange, L. A., Woo, D., Unverzagt, F. W., Safford, M., Cushman, M., Limdi, N., Quarells, R., Arnett, D. K., Irvin, M. R., & Zhi, D. (2019). A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study. BMC Medical Genomics, 12, [26]. https://doi.org/10.1186/s12920-018-0462-7