A pilot study of D-cycloserine in subjects with autistic disorder

David J. Posey, Deborah L. Kem, Naomi B. Swiezy, Thayne L. Sweeten, Ryan E. Wiegand, Christopher J. McDougle

Research output: Contribution to journalArticle

143 Scopus citations


Objective: The authors assessed the effects of D-cycloserine on the core symptom of social impairment in subjects with autism. Method: Following a 2-week, single-blind placebo lead-in phase, drug-free subjects with autistic disorder were administered three different doses of D-cycloserine during each of three 2-week periods. Measures used for subject ratings included the Clinical Global Impression (CGI) scale and Aberrant Behavior Checklist. Results: Significant improvement was found on the CGI and social withdrawal subscale of the Aberrant Behavior Checklist. D-Cycloserine was well tolerated at most of the doses used in this study. Conclusions: In this pilot study, D-cycloserine treatment resulted in significant improvement in social withdrawal. Further controlled studies of D-cycloserine in autism appear warranted.

Original languageEnglish (US)
Pages (from-to)2115-2117
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number11
StatePublished - Nov 2004

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Posey, D. J., Kem, D. L., Swiezy, N. B., Sweeten, T. L., Wiegand, R. E., & McDougle, C. J. (2004). A pilot study of D-cycloserine in subjects with autistic disorder. American Journal of Psychiatry, 161(11), 2115-2117. https://doi.org/10.1176/appi.ajp.161.11.2115