A pilot study using roptool to measure retinal vascular dilation

David K. Wallace, Sharon F. Freedman, Zheen Zhao

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Plus disease is abnormal retinal vascular dilation and tortuosity, and it is now the primary indication for laser treatment in retinopathy of prematurity (ROP). ROPtool is a computer program that measures retinal arteriolar tortuosity. Our aim was to assess the accuracy of ROPtool's newly developed measurement of retinal vascular width (dilation). Methods: ROPtool was used to measure the width of 154 blood vessels in 20 high-quality RetCam images from 20 premature infants. ROPtool's accuracy was determined by comparing results with the mean grades of 2 authors who scored retinal vascular dilation using a 10-point scale. Results: There was very good correlation (r = 0.80) between ROPtool's measurement of retinal vascular dilation and author judgment. Areas under receiver operating characteristics curves for identification of dilation sufficient for plus disease and for pre-plus disease were 0.93 and 0.90, respectively. At an optimal point on the receiver operating characteristics curve, ROPtool's sensitivity for diagnosing dilation sufficient for plus disease was 89% (24/27), and its specificity was 83% (106/127). Conclusion: In addition to measuring retinal vascular tortuosity, ROPtool now accurately measures retinal vascular width in high-quality RetCam images. Application of this technology has the potential to remove subjectivity from the assessment of plus disease.

Original languageEnglish (US)
Pages (from-to)1182-1187
Number of pages6
JournalRetina
Volume29
Issue number8
DOIs
StatePublished - Sep 1 2009

Fingerprint

Retinal Vessels
Dilatation
ROC Curve
Retinopathy of Prematurity
Premature Infants
Blood Vessels
Lasers
Software
Technology

Keywords

  • Computer-assisted quantification
  • Plus disease
  • Pre-plus disease
  • ROPtool
  • Retinal vascular dilation
  • Retinopathy of prematurity
  • Vessel width

ASJC Scopus subject areas

  • Ophthalmology

Cite this

A pilot study using roptool to measure retinal vascular dilation. / Wallace, David K.; Freedman, Sharon F.; Zhao, Zheen.

In: Retina, Vol. 29, No. 8, 01.09.2009, p. 1182-1187.

Research output: Contribution to journalArticle

Wallace, David K. ; Freedman, Sharon F. ; Zhao, Zheen. / A pilot study using roptool to measure retinal vascular dilation. In: Retina. 2009 ; Vol. 29, No. 8. pp. 1182-1187.
@article{42e9e029a9034af8ad9c36706dac504d,
title = "A pilot study using roptool to measure retinal vascular dilation",
abstract = "Background: Plus disease is abnormal retinal vascular dilation and tortuosity, and it is now the primary indication for laser treatment in retinopathy of prematurity (ROP). ROPtool is a computer program that measures retinal arteriolar tortuosity. Our aim was to assess the accuracy of ROPtool's newly developed measurement of retinal vascular width (dilation). Methods: ROPtool was used to measure the width of 154 blood vessels in 20 high-quality RetCam images from 20 premature infants. ROPtool's accuracy was determined by comparing results with the mean grades of 2 authors who scored retinal vascular dilation using a 10-point scale. Results: There was very good correlation (r = 0.80) between ROPtool's measurement of retinal vascular dilation and author judgment. Areas under receiver operating characteristics curves for identification of dilation sufficient for plus disease and for pre-plus disease were 0.93 and 0.90, respectively. At an optimal point on the receiver operating characteristics curve, ROPtool's sensitivity for diagnosing dilation sufficient for plus disease was 89{\%} (24/27), and its specificity was 83{\%} (106/127). Conclusion: In addition to measuring retinal vascular tortuosity, ROPtool now accurately measures retinal vascular width in high-quality RetCam images. Application of this technology has the potential to remove subjectivity from the assessment of plus disease.",
keywords = "Computer-assisted quantification, Plus disease, Pre-plus disease, ROPtool, Retinal vascular dilation, Retinopathy of prematurity, Vessel width",
author = "Wallace, {David K.} and Freedman, {Sharon F.} and Zheen Zhao",
year = "2009",
month = "9",
day = "1",
doi = "10.1097/IAE.0b013e3181a46a73",
language = "English (US)",
volume = "29",
pages = "1182--1187",
journal = "Retina",
issn = "0275-004X",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - A pilot study using roptool to measure retinal vascular dilation

AU - Wallace, David K.

AU - Freedman, Sharon F.

AU - Zhao, Zheen

PY - 2009/9/1

Y1 - 2009/9/1

N2 - Background: Plus disease is abnormal retinal vascular dilation and tortuosity, and it is now the primary indication for laser treatment in retinopathy of prematurity (ROP). ROPtool is a computer program that measures retinal arteriolar tortuosity. Our aim was to assess the accuracy of ROPtool's newly developed measurement of retinal vascular width (dilation). Methods: ROPtool was used to measure the width of 154 blood vessels in 20 high-quality RetCam images from 20 premature infants. ROPtool's accuracy was determined by comparing results with the mean grades of 2 authors who scored retinal vascular dilation using a 10-point scale. Results: There was very good correlation (r = 0.80) between ROPtool's measurement of retinal vascular dilation and author judgment. Areas under receiver operating characteristics curves for identification of dilation sufficient for plus disease and for pre-plus disease were 0.93 and 0.90, respectively. At an optimal point on the receiver operating characteristics curve, ROPtool's sensitivity for diagnosing dilation sufficient for plus disease was 89% (24/27), and its specificity was 83% (106/127). Conclusion: In addition to measuring retinal vascular tortuosity, ROPtool now accurately measures retinal vascular width in high-quality RetCam images. Application of this technology has the potential to remove subjectivity from the assessment of plus disease.

AB - Background: Plus disease is abnormal retinal vascular dilation and tortuosity, and it is now the primary indication for laser treatment in retinopathy of prematurity (ROP). ROPtool is a computer program that measures retinal arteriolar tortuosity. Our aim was to assess the accuracy of ROPtool's newly developed measurement of retinal vascular width (dilation). Methods: ROPtool was used to measure the width of 154 blood vessels in 20 high-quality RetCam images from 20 premature infants. ROPtool's accuracy was determined by comparing results with the mean grades of 2 authors who scored retinal vascular dilation using a 10-point scale. Results: There was very good correlation (r = 0.80) between ROPtool's measurement of retinal vascular dilation and author judgment. Areas under receiver operating characteristics curves for identification of dilation sufficient for plus disease and for pre-plus disease were 0.93 and 0.90, respectively. At an optimal point on the receiver operating characteristics curve, ROPtool's sensitivity for diagnosing dilation sufficient for plus disease was 89% (24/27), and its specificity was 83% (106/127). Conclusion: In addition to measuring retinal vascular tortuosity, ROPtool now accurately measures retinal vascular width in high-quality RetCam images. Application of this technology has the potential to remove subjectivity from the assessment of plus disease.

KW - Computer-assisted quantification

KW - Plus disease

KW - Pre-plus disease

KW - ROPtool

KW - Retinal vascular dilation

KW - Retinopathy of prematurity

KW - Vessel width

UR - http://www.scopus.com/inward/record.url?scp=70349121755&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349121755&partnerID=8YFLogxK

U2 - 10.1097/IAE.0b013e3181a46a73

DO - 10.1097/IAE.0b013e3181a46a73

M3 - Article

C2 - 19491720

AN - SCOPUS:70349121755

VL - 29

SP - 1182

EP - 1187

JO - Retina

JF - Retina

SN - 0275-004X

IS - 8

ER -