A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study

David Kareken, Tiebing Liang, Leah Wetherill, Mario Dzemidzic, Veronique Bragulat, Cari Cox, Thomas Talavage, Sean O'Connor, Tatiana Foroud

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: Significant evidence has accumulated to suggest an association between single-nucleotide polymorphisms (SNPs) in the GABRA2 gene and alcoholism. However, research has yet to show an association between these polymorphisms and the human brain's reward system function. In this study, we stratified subjects who had participated in an fMRI study of alcohol cue responses according to their genotype at a SNP in GABRA2 (rs279871) shown to be associated with alcohol dependence (Edenberg et al., 2004). Methods: Genotyping showed 13 subjects to be homozygous for the high-risk allele (AA), and 23 subjects to be heterozygous (AG). In fMRI, subjects were exposed to the aromas of their preferred alcoholic drink odors (AO), as well as to appetitive control odors (ApCO) under both alcohol intoxication and placebo control conditions. Results: Homozygous AA subjects had a larger [AO > ApCO] response than did AG subjects in medial frontal cortical areas thought to code reward value. However, AG subjects had a larger [AO > ApCO] effect in the ventral tegmental area. Alcohol intoxication did not alter these group differences. Conclusions: These are the first data to suggest that GABRA2 genotype could affect the brain's responses to cues associated with alcohol.

Original languageEnglish
Pages (from-to)2169-2178
Number of pages10
JournalAlcoholism: Clinical and Experimental Research
Volume34
Issue number12
DOIs
StatePublished - Dec 2010

Fingerprint

Polymorphism
Cues
Odor control
Alcohols
Magnetic Resonance Imaging
Odors
Alcoholic Intoxication
Brain
Reward
Nucleotides
Alcoholism
Single Nucleotide Polymorphism
Genotype
Ventral Tegmental Area
Genes
Odorants
Alleles
Placebos
Alcoholic beverages
Research

Keywords

  • Addiction
  • Genetics
  • Neuroimaging
  • Olfaction
  • Reward
  • Risk

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study. / Kareken, David; Liang, Tiebing; Wetherill, Leah; Dzemidzic, Mario; Bragulat, Veronique; Cox, Cari; Talavage, Thomas; O'Connor, Sean; Foroud, Tatiana.

In: Alcoholism: Clinical and Experimental Research, Vol. 34, No. 12, 12.2010, p. 2169-2178.

Research output: Contribution to journalArticle

@article{d43a5981c5c14d8f9fc1d999d135a42c,
title = "A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study",
abstract = "Background: Significant evidence has accumulated to suggest an association between single-nucleotide polymorphisms (SNPs) in the GABRA2 gene and alcoholism. However, research has yet to show an association between these polymorphisms and the human brain's reward system function. In this study, we stratified subjects who had participated in an fMRI study of alcohol cue responses according to their genotype at a SNP in GABRA2 (rs279871) shown to be associated with alcohol dependence (Edenberg et al., 2004). Methods: Genotyping showed 13 subjects to be homozygous for the high-risk allele (AA), and 23 subjects to be heterozygous (AG). In fMRI, subjects were exposed to the aromas of their preferred alcoholic drink odors (AO), as well as to appetitive control odors (ApCO) under both alcohol intoxication and placebo control conditions. Results: Homozygous AA subjects had a larger [AO > ApCO] response than did AG subjects in medial frontal cortical areas thought to code reward value. However, AG subjects had a larger [AO > ApCO] effect in the ventral tegmental area. Alcohol intoxication did not alter these group differences. Conclusions: These are the first data to suggest that GABRA2 genotype could affect the brain's responses to cues associated with alcohol.",
keywords = "Addiction, Genetics, Neuroimaging, Olfaction, Reward, Risk",
author = "David Kareken and Tiebing Liang and Leah Wetherill and Mario Dzemidzic and Veronique Bragulat and Cari Cox and Thomas Talavage and Sean O'Connor and Tatiana Foroud",
year = "2010",
month = "12",
doi = "10.1111/j.1530-0277.2010.01293.x",
language = "English",
volume = "34",
pages = "2169--2178",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "12",

}

TY - JOUR

T1 - A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study

AU - Kareken, David

AU - Liang, Tiebing

AU - Wetherill, Leah

AU - Dzemidzic, Mario

AU - Bragulat, Veronique

AU - Cox, Cari

AU - Talavage, Thomas

AU - O'Connor, Sean

AU - Foroud, Tatiana

PY - 2010/12

Y1 - 2010/12

N2 - Background: Significant evidence has accumulated to suggest an association between single-nucleotide polymorphisms (SNPs) in the GABRA2 gene and alcoholism. However, research has yet to show an association between these polymorphisms and the human brain's reward system function. In this study, we stratified subjects who had participated in an fMRI study of alcohol cue responses according to their genotype at a SNP in GABRA2 (rs279871) shown to be associated with alcohol dependence (Edenberg et al., 2004). Methods: Genotyping showed 13 subjects to be homozygous for the high-risk allele (AA), and 23 subjects to be heterozygous (AG). In fMRI, subjects were exposed to the aromas of their preferred alcoholic drink odors (AO), as well as to appetitive control odors (ApCO) under both alcohol intoxication and placebo control conditions. Results: Homozygous AA subjects had a larger [AO > ApCO] response than did AG subjects in medial frontal cortical areas thought to code reward value. However, AG subjects had a larger [AO > ApCO] effect in the ventral tegmental area. Alcohol intoxication did not alter these group differences. Conclusions: These are the first data to suggest that GABRA2 genotype could affect the brain's responses to cues associated with alcohol.

AB - Background: Significant evidence has accumulated to suggest an association between single-nucleotide polymorphisms (SNPs) in the GABRA2 gene and alcoholism. However, research has yet to show an association between these polymorphisms and the human brain's reward system function. In this study, we stratified subjects who had participated in an fMRI study of alcohol cue responses according to their genotype at a SNP in GABRA2 (rs279871) shown to be associated with alcohol dependence (Edenberg et al., 2004). Methods: Genotyping showed 13 subjects to be homozygous for the high-risk allele (AA), and 23 subjects to be heterozygous (AG). In fMRI, subjects were exposed to the aromas of their preferred alcoholic drink odors (AO), as well as to appetitive control odors (ApCO) under both alcohol intoxication and placebo control conditions. Results: Homozygous AA subjects had a larger [AO > ApCO] response than did AG subjects in medial frontal cortical areas thought to code reward value. However, AG subjects had a larger [AO > ApCO] effect in the ventral tegmental area. Alcohol intoxication did not alter these group differences. Conclusions: These are the first data to suggest that GABRA2 genotype could affect the brain's responses to cues associated with alcohol.

KW - Addiction

KW - Genetics

KW - Neuroimaging

KW - Olfaction

KW - Reward

KW - Risk

UR - http://www.scopus.com/inward/record.url?scp=78649532363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649532363&partnerID=8YFLogxK

U2 - 10.1111/j.1530-0277.2010.01293.x

DO - 10.1111/j.1530-0277.2010.01293.x

M3 - Article

C2 - 20698837

AN - SCOPUS:78649532363

VL - 34

SP - 2169

EP - 2178

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 12

ER -