A Population-Based Analysis of 1037 Malignant Ovarian Tumors in the Pediatric Population

Kathleen F. Brookfield, Michael C. Cheung, Leonidas Koniaris, Juan E. Sola, Anne C. Fischer

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background: Concerns of malignant potential have impacted the utilization of ovarian salvage for treatment of ovarian masses in children. Methods: The Surveillance, Epidemiology, and End Results (SEER) registry was analyzed for all females ≤ 19 y diagnosed with an ovarian tumor between 1973 and 2005. Results: Overall, 1037 pediatric patients with ovarian tumors were identified. Approximately 61.7% of tumors occurred in patients 15 to 19 y old. The age-adjusted incidence of all malignant pediatric ovarian tumors in those ≤ 9 y was 0.102 versus 1.072 per 100,000 in those aged 10 to 19 y. The majority of cases (57.4%) present at an early localized stage. The predominant pathology was germ cell tumors in all age groups (77.4%). Overall 5- and 10-y survival rates are 91.7% and 91.4%, respectively. By multivariate analysis, advanced disease stage (HR 3.17, P <0.001), lack of surgery (HR 4.49, P = 0.039), and poorly differentiated tumors (HR 3.40, P = 0.011) were associated with worse outcomes. Conclusions: Malignant ovarian tumors are rare, particularly in patients under 5 y of age. Furthermore, the most common histologies are of low metastatic potential and carry high cure rates. Thus, the surgeon should implement ovarian-sparing strategies on the affected ovary unless a malignancy is clearly suspected and conserve the contralateral ovary in all children.

Original languageEnglish (US)
Pages (from-to)45-49
Number of pages5
JournalJournal of Surgical Research
Volume156
Issue number1
DOIs
StatePublished - Sep 2009
Externally publishedYes

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Pediatrics
Population
Neoplasms
Ovary
Salvage Therapy
Germ Cell and Embryonal Neoplasms
Registries
Histology
Epidemiology
Multivariate Analysis
Survival Rate
Age Groups
Pathology
Incidence

Keywords

  • germ cell
  • malignancy
  • ovarian
  • pediatric
  • stromal cell tumors
  • yolk sac tumors

ASJC Scopus subject areas

  • Surgery

Cite this

A Population-Based Analysis of 1037 Malignant Ovarian Tumors in the Pediatric Population. / Brookfield, Kathleen F.; Cheung, Michael C.; Koniaris, Leonidas; Sola, Juan E.; Fischer, Anne C.

In: Journal of Surgical Research, Vol. 156, No. 1, 09.2009, p. 45-49.

Research output: Contribution to journalArticle

Brookfield, Kathleen F. ; Cheung, Michael C. ; Koniaris, Leonidas ; Sola, Juan E. ; Fischer, Anne C. / A Population-Based Analysis of 1037 Malignant Ovarian Tumors in the Pediatric Population. In: Journal of Surgical Research. 2009 ; Vol. 156, No. 1. pp. 45-49.
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