A population PK model for citalopram and its major metabolite, N-desmethyl citalopram, in rats

Nieves Velez de Mendizabal, Kimberley Jackson, Brian Eastwood, Steven Swanson, David M. Bender, Stephen Lowe, Robert Bies

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A population PK model was developed in order to simultaneously describe citalopram and its major metabolite, n-desmethyl citalopram, plasma concentrations in two different strain of rats after intravenous (IV) and oral (PO) administration of citalopram. Citalopram was administered to Sprague–Dawley (SD) rats at doses: 0.3, 1, 3, and 10 mg/kg IV and 10 mg/kg PO. The compound was dosed orally to Wistar rats at doses: 0.3, 1, 3, 10, 30 and 60 mg/kg. Plasma samples were collected for citalopram and metabolite. Pharmacokinetic analyses were conducted using NONMEM 7.2. Values below the quantification limit (BLQ

Original languageEnglish (US)
Pages (from-to)721-733
Number of pages13
JournalJournal of Pharmacokinetics and Pharmacodynamics
Volume42
Issue number6
DOIs
StatePublished - Sep 22 2015

Keywords

  • Citalopram
  • Metabolite
  • N-desmethyl citalopram
  • NONMEM

ASJC Scopus subject areas

  • Pharmacology

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