Phosphate metabolism is critical to multiple systems andcellular functions. Disruption of any point in the pathwaysof phosphate metabolism may cause serum phosphate abnormalities and resultant acute or chronic clinicalconditions. The study of phosphate disorders hasrevealed a wealth of information regarding normal phosphatephysiology. Careful evaluation of affected patientsbased on pathophysiologic assessments will usuallyidentify the aetiology of hypophosphataemia or hyperphosphataemia,therapy. Because of the relative importance of chronic hypophosphataemia and hyperphosphataemia to bonedisease, much of this chapter will focus on chronic disorders,especially those mediated by excess or deficient fibroblastgrowth factor 23 functioning.
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