A practical diastereoselective synthesis of β-amino-α-hydroxy carboxylates

Jae Mok Lee, Hyun-Suk Lim, Kyung Chang Seo, Sung Kee Chung

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Practical synthetic routes to β-amino-α-hydroxy carboxylates (AHC) have been developed from amino acids. Reduction of β-amino-α- keto esters 6 with NaBH4 was found to give anti-AHCs 7 in high de, which were efficiently converted to the corresponding syn-AHCs 8 via oxazolidine ring 10 formation.

Original languageEnglish (US)
Pages (from-to)3639-3641
Number of pages3
JournalTetrahedron Asymmetry
Volume14
Issue number23
DOIs
StatePublished - Nov 28 2003
Externally publishedYes

Fingerprint

carboxylates
amino acids
Amino acids
esters
Esters
routes
Amino Acids
rings
synthesis
oxazolidine

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

A practical diastereoselective synthesis of β-amino-α-hydroxy carboxylates. / Lee, Jae Mok; Lim, Hyun-Suk; Seo, Kyung Chang; Chung, Sung Kee.

In: Tetrahedron Asymmetry, Vol. 14, No. 23, 28.11.2003, p. 3639-3641.

Research output: Contribution to journalArticle

Lee, Jae Mok ; Lim, Hyun-Suk ; Seo, Kyung Chang ; Chung, Sung Kee. / A practical diastereoselective synthesis of β-amino-α-hydroxy carboxylates. In: Tetrahedron Asymmetry. 2003 ; Vol. 14, No. 23. pp. 3639-3641.
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